Degradable polymeric bio(nano)materials and their biomedical applications: a comprehensive overview and recent updates. Ketan Kuperkar, Leonard Ionut Atanase, Anita Bahadur, Ioana Cristina Crivei, and Pratap Bahadur review the latest developments in degradable polymers for biomedical use. These materials, including natural and synthetic polymers like polysaccharides, proteins, and polyesters, are valued for their biocompatibility, flexibility, and minimal side effects. The review discusses various methods to modify these polymers, such as cross-linking, nanocomposites, and functionalization, to enhance their properties for biomedical applications. It covers degradation mechanisms, drug delivery, tissue engineering, and regenerative medicine. The authors highlight the importance of degradable polymers in drug delivery systems, biosensors, and wound healing. They also discuss the challenges in translating these materials to clinical applications, emphasizing the need for further research to optimize their properties for biomedical use. The review includes examples of various degradable polymers, such as polyesters, polyamino acids, polyanhydrides, polyphosphazenes, and polyurethanes, and their applications in biomedical fields. The authors conclude that degradable polymeric materials have significant potential in biomedical applications, but further research is needed to fully realize their potential.Degradable polymeric bio(nano)materials and their biomedical applications: a comprehensive overview and recent updates. Ketan Kuperkar, Leonard Ionut Atanase, Anita Bahadur, Ioana Cristina Crivei, and Pratap Bahadur review the latest developments in degradable polymers for biomedical use. These materials, including natural and synthetic polymers like polysaccharides, proteins, and polyesters, are valued for their biocompatibility, flexibility, and minimal side effects. The review discusses various methods to modify these polymers, such as cross-linking, nanocomposites, and functionalization, to enhance their properties for biomedical applications. It covers degradation mechanisms, drug delivery, tissue engineering, and regenerative medicine. The authors highlight the importance of degradable polymers in drug delivery systems, biosensors, and wound healing. They also discuss the challenges in translating these materials to clinical applications, emphasizing the need for further research to optimize their properties for biomedical use. The review includes examples of various degradable polymers, such as polyesters, polyamino acids, polyanhydrides, polyphosphazenes, and polyurethanes, and their applications in biomedical fields. The authors conclude that degradable polymeric materials have significant potential in biomedical applications, but further research is needed to fully realize their potential.