The article provides a comprehensive overview of degradable polymers and their biomedical applications. Degradable polymers, both natural and synthetic, are promising due to their low cost, biocompatibility, flexibility, and minimal side effects. The paper discusses various types of polymers, including polysaccharides, proteins, polyesters, polyamino acids, polyanhydrides, polyphosphazenes, and polyurethanes. It covers the transformation of these polymers through physical and chemical means, such as cross-linking, blending, and functionalization, and their degradation mechanisms. The biomedical applications of these polymers in wound dressing, biosensors, drug delivery systems, tissue engineering, and regenerative medicine are highlighted. The article also reviews the use of nano systems in drug delivery and the challenges and advancements in this field. Key polymers like polylactic acid (PLA), poly(lactic-co-glycolic acid) (PLGA), poly(ε-caprolactone) (PCL), and poly(aspartic acid) are discussed in detail, along with their properties and applications. The article concludes by emphasizing the potential of degradable polymers in advancing biomedical technologies.The article provides a comprehensive overview of degradable polymers and their biomedical applications. Degradable polymers, both natural and synthetic, are promising due to their low cost, biocompatibility, flexibility, and minimal side effects. The paper discusses various types of polymers, including polysaccharides, proteins, polyesters, polyamino acids, polyanhydrides, polyphosphazenes, and polyurethanes. It covers the transformation of these polymers through physical and chemical means, such as cross-linking, blending, and functionalization, and their degradation mechanisms. The biomedical applications of these polymers in wound dressing, biosensors, drug delivery systems, tissue engineering, and regenerative medicine are highlighted. The article also reviews the use of nano systems in drug delivery and the challenges and advancements in this field. Key polymers like polylactic acid (PLA), poly(lactic-co-glycolic acid) (PLGA), poly(ε-caprolactone) (PCL), and poly(aspartic acid) are discussed in detail, along with their properties and applications. The article concludes by emphasizing the potential of degradable polymers in advancing biomedical technologies.