The article "Dengue, Urbanization and Globalization: The Unholy Trinity of the 21st Century" by Duane J. Gubler discusses the increasing prevalence and impact of dengue fever, a significant arboviral disease affecting over half of the world's population. The authors attribute the rise in epidemic dengue to three primary factors: urbanization, globalization, and the lack of effective mosquito control. Urbanization has led to dense human populations living in close proximity to large mosquito populations, creating ideal conditions for virus transmission. Globalization, driven by economic growth and modern air transport, has facilitated the rapid spread of dengue viruses to new regions. The failure to control *Aedes aegypti* mosquitoes, a primary vector, has further exacerbated the problem. The article highlights the challenges in measuring the true burden of dengue due to underreporting, misdiagnosis, and inadequate surveillance systems. It also emphasizes the need for integrated approaches, including improved mosquito control, vaccines, and antiviral drugs, to combat the disease. Despite ongoing efforts, the authors predict that without significant changes in policy and resources, the incidence and geographic spread of dengue will continue to increase.The article "Dengue, Urbanization and Globalization: The Unholy Trinity of the 21st Century" by Duane J. Gubler discusses the increasing prevalence and impact of dengue fever, a significant arboviral disease affecting over half of the world's population. The authors attribute the rise in epidemic dengue to three primary factors: urbanization, globalization, and the lack of effective mosquito control. Urbanization has led to dense human populations living in close proximity to large mosquito populations, creating ideal conditions for virus transmission. Globalization, driven by economic growth and modern air transport, has facilitated the rapid spread of dengue viruses to new regions. The failure to control *Aedes aegypti* mosquitoes, a primary vector, has further exacerbated the problem. The article highlights the challenges in measuring the true burden of dengue due to underreporting, misdiagnosis, and inadequate surveillance systems. It also emphasizes the need for integrated approaches, including improved mosquito control, vaccines, and antiviral drugs, to combat the disease. Despite ongoing efforts, the authors predict that without significant changes in policy and resources, the incidence and geographic spread of dengue will continue to increase.