This review discusses the second edition of the book "Depression: Causes and Treatment" by Vivian Mascella, published in 2013. The book is divided into four parts: clinical aspects, experimental aspects, theoretical aspects, and treatment of depression. It covers the definition, symptoms, course, and prognosis of depression, as well as various types of mood disorders. The book also explores biological and psychological studies, theories of depression, and the development of depression. In terms of treatment, it discusses somatic therapies, psychotherapy, and the assessment of treatments through randomized controlled trials. The review highlights the historical context of depression, its prevalence, and the challenges in understanding its nature and etiology. It also notes the lack of basic knowledge about the biological substrate of depression and the need for further research in certain areas, such as schizoaffective disorder. The book is valuable for professionals in psychology and psychiatry, providing a comprehensive overview of depression and its management.This review discusses the second edition of the book "Depression: Causes and Treatment" by Vivian Mascella, published in 2013. The book is divided into four parts: clinical aspects, experimental aspects, theoretical aspects, and treatment of depression. It covers the definition, symptoms, course, and prognosis of depression, as well as various types of mood disorders. The book also explores biological and psychological studies, theories of depression, and the development of depression. In terms of treatment, it discusses somatic therapies, psychotherapy, and the assessment of treatments through randomized controlled trials. The review highlights the historical context of depression, its prevalence, and the challenges in understanding its nature and etiology. It also notes the lack of basic knowledge about the biological substrate of depression and the need for further research in certain areas, such as schizoaffective disorder. The book is valuable for professionals in psychology and psychiatry, providing a comprehensive overview of depression and its management.