Cardiovascular disease (CVD) and depression are prevalent conditions that significantly impact patients' quality of life and prognosis. Patients with CVD have a higher prevalence of depression compared to the general population, and those with depression are at increased risk of developing CVD and have worse outcomes. The relationship between the two conditions is bidirectional, with depression potentially being a marker for more severe CVD or a causal factor. Depression in CVD patients is often an adjustment disorder that can improve with comprehensive cardiac management, but it can also persist and lead to major depressive disorder. Major depressive disorder in CVD patients is associated with higher mortality and morbidity rates. Management strategies include cardiac rehabilitation, exercise programs, cognitive behavioral therapy, antidepressant medication, and combined approaches. Social support and disease management programs are also important for improving outcomes. Screening for depression is recommended for all post-acute cardiac event patients and chronic heart failure patients, with regular follow-up to monitor and manage depression.Cardiovascular disease (CVD) and depression are prevalent conditions that significantly impact patients' quality of life and prognosis. Patients with CVD have a higher prevalence of depression compared to the general population, and those with depression are at increased risk of developing CVD and have worse outcomes. The relationship between the two conditions is bidirectional, with depression potentially being a marker for more severe CVD or a causal factor. Depression in CVD patients is often an adjustment disorder that can improve with comprehensive cardiac management, but it can also persist and lead to major depressive disorder. Major depressive disorder in CVD patients is associated with higher mortality and morbidity rates. Management strategies include cardiac rehabilitation, exercise programs, cognitive behavioral therapy, antidepressant medication, and combined approaches. Social support and disease management programs are also important for improving outcomes. Screening for depression is recommended for all post-acute cardiac event patients and chronic heart failure patients, with regular follow-up to monitor and manage depression.