This study explores the development of Technological Pedagogical Content Knowledge (TPCK) in science teacher education, focusing on integrating technology with a Research Teaching Perspective (RTP). The research employs a design-based approach, involving interviews, questionnaires, and participant observation to assess the effectiveness of an in-service science teacher education course. The study aims to identify curriculum components that enhance teachers' TPCK and evaluate the impact of the course on their professional development. Results show that integrating technology with RTP can foster innovative science lessons and improve teachers' understanding of available technology. The study proposes a design framework for developing TPCK in initial and in-service science teachers, emphasizing the importance of collaboration, action-research projects, and the integration of content, pedagogy, and technology. The framework is designed to support teachers in using technology to enhance scientific literacy and critical thinking in their classrooms.This study explores the development of Technological Pedagogical Content Knowledge (TPCK) in science teacher education, focusing on integrating technology with a Research Teaching Perspective (RTP). The research employs a design-based approach, involving interviews, questionnaires, and participant observation to assess the effectiveness of an in-service science teacher education course. The study aims to identify curriculum components that enhance teachers' TPCK and evaluate the impact of the course on their professional development. Results show that integrating technology with RTP can foster innovative science lessons and improve teachers' understanding of available technology. The study proposes a design framework for developing TPCK in initial and in-service science teachers, emphasizing the importance of collaboration, action-research projects, and the integration of content, pedagogy, and technology. The framework is designed to support teachers in using technology to enhance scientific literacy and critical thinking in their classrooms.