This study examines the determinants of COVID-19 vaccine acceptance in the United States. Using an online survey of 672 U.S. adults in May 2020, the researchers found that 67% of participants would accept a COVID-19 vaccine if recommended. Key demographic factors influencing vaccine acceptance include gender, age, race, education, and employment status. Males, older adults, Asians, and college/graduate degree holders were more likely to accept the vaccine. The study also identified geographic disparities, with higher acceptance rates in Denver (Region 8) and lower rates in New York (Region 2) and Chicago (Region 5). Participants' trust in healthcare professionals and health officials was high, and they reported the highest confidence in these sources for COVID-19 information. The findings highlight the need for targeted, evidence-based messaging to improve vaccine acceptance, especially among vulnerable populations. The study suggests that effective communication strategies are crucial to achieving herd immunity and controlling the pandemic.This study examines the determinants of COVID-19 vaccine acceptance in the United States. Using an online survey of 672 U.S. adults in May 2020, the researchers found that 67% of participants would accept a COVID-19 vaccine if recommended. Key demographic factors influencing vaccine acceptance include gender, age, race, education, and employment status. Males, older adults, Asians, and college/graduate degree holders were more likely to accept the vaccine. The study also identified geographic disparities, with higher acceptance rates in Denver (Region 8) and lower rates in New York (Region 2) and Chicago (Region 5). Participants' trust in healthcare professionals and health officials was high, and they reported the highest confidence in these sources for COVID-19 information. The findings highlight the need for targeted, evidence-based messaging to improve vaccine acceptance, especially among vulnerable populations. The study suggests that effective communication strategies are crucial to achieving herd immunity and controlling the pandemic.