This study explores the development of technopreneurial skills to address future challenges in a rapidly evolving globalized and technologically advanced world. The research uses SmartPLS to analyze the relationship between entrepreneurial education, work experience, and technological readiness with technopreneurial skills, finding a significant positive impact. Innovation is identified as a mediating variable that bridges the gap between theoretical knowledge and practical application. The study emphasizes the need for educational institutions and industry stakeholders to integrate practical training and innovative thinking into their programs to better prepare students for the future. The findings provide a framework for designing and evaluating effective entrepreneurship programs, highlighting the importance of a holistic approach that combines technical expertise with entrepreneurial acumen.This study explores the development of technopreneurial skills to address future challenges in a rapidly evolving globalized and technologically advanced world. The research uses SmartPLS to analyze the relationship between entrepreneurial education, work experience, and technological readiness with technopreneurial skills, finding a significant positive impact. Innovation is identified as a mediating variable that bridges the gap between theoretical knowledge and practical application. The study emphasizes the need for educational institutions and industry stakeholders to integrate practical training and innovative thinking into their programs to better prepare students for the future. The findings provide a framework for designing and evaluating effective entrepreneurship programs, highlighting the importance of a holistic approach that combines technical expertise with entrepreneurial acumen.