This study explores the development of technopreneur skills to address future challenges in a globalized and technologically advanced world. Using SmartPLS, the research investigates the relationship between entrepreneurial education, work experience, and technological readiness with technopreneurial skills, with innovation as a mediating variable. The findings reveal that entrepreneurial education, work experience, and technological readiness significantly influence technopreneurial skills. Innovation plays a crucial role in mediating these relationships, highlighting its importance in transforming educational and experiential inputs into practical technopreneurial outcomes. The study emphasizes the need for educational institutions and industry stakeholders to provide programs and training focused on technopreneurial skills, not only theoretically but also in practice. It suggests that integrating technical and entrepreneurial education, along with experiential learning, can better prepare students for the challenges of the future. The research also underscores the importance of innovation in bridging the gap between academic knowledge and entrepreneurial success. The study's implications suggest that educational programs should incorporate technology-focused curricula and practical experiences to develop a holistic understanding of technological innovations in entrepreneurial contexts. By fostering innovation, interdisciplinary collaboration, and experiential learning, institutions can better equip students to navigate the complexities of the modern business landscape and achieve entrepreneurial success. The findings validate the proposed model, demonstrating the significant relationships between entrepreneurial education, work experience, technological readiness, innovation, and technopreneurial competencies. These results provide practical guidance for curriculum developers and educators aiming to enhance the entrepreneurial capabilities of engineering and business students. The study highlights the necessity for educational institutions to adopt an integrative approach that combines theoretical knowledge with practical technology-driven experiences to better prepare future professionals for the evolving demands of the technopreneurship landscape.This study explores the development of technopreneur skills to address future challenges in a globalized and technologically advanced world. Using SmartPLS, the research investigates the relationship between entrepreneurial education, work experience, and technological readiness with technopreneurial skills, with innovation as a mediating variable. The findings reveal that entrepreneurial education, work experience, and technological readiness significantly influence technopreneurial skills. Innovation plays a crucial role in mediating these relationships, highlighting its importance in transforming educational and experiential inputs into practical technopreneurial outcomes. The study emphasizes the need for educational institutions and industry stakeholders to provide programs and training focused on technopreneurial skills, not only theoretically but also in practice. It suggests that integrating technical and entrepreneurial education, along with experiential learning, can better prepare students for the challenges of the future. The research also underscores the importance of innovation in bridging the gap between academic knowledge and entrepreneurial success. The study's implications suggest that educational programs should incorporate technology-focused curricula and practical experiences to develop a holistic understanding of technological innovations in entrepreneurial contexts. By fostering innovation, interdisciplinary collaboration, and experiential learning, institutions can better equip students to navigate the complexities of the modern business landscape and achieve entrepreneurial success. The findings validate the proposed model, demonstrating the significant relationships between entrepreneurial education, work experience, technological readiness, innovation, and technopreneurial competencies. These results provide practical guidance for curriculum developers and educators aiming to enhance the entrepreneurial capabilities of engineering and business students. The study highlights the necessity for educational institutions to adopt an integrative approach that combines theoretical knowledge with practical technology-driven experiences to better prepare future professionals for the evolving demands of the technopreneurship landscape.