This review discusses the properties, modification, cross-linking, and applications of fibrin-based biomaterials in tissue engineering. Fibrin is a natural protein that forms a scaffold after tissue injury, offering high biocompatibility, non-toxicity, and low immunogenicity. It plays a critical role in cell adhesion, migration, proliferation, and wound healing. Fibrin scaffolds are widely used in tissue engineering to repair or enhance the function of damaged tissues and organs. The review covers the composition, structure, and biological properties of fibrin, as well as its modification and cross-linking methods. It also discusses various forms of fibrin used in tissue engineering, including fibrin hydrogels, fibrin glue, and fibrin microbeads. The review highlights the potential of fibrin scaffolds in applications such as skin, bone, and cardiac tissue regeneration. It also discusses the mechanical properties of fibrin, including its viscoelastic characteristics and strain-hardening behavior, which are important for tissue engineering applications. The degradation properties of fibrin are also discussed, as well as the changes in fibrin during tissue damage. The review concludes that fibrin scaffolds have significant potential in tissue engineering due to their biocompatibility, mechanical properties, and ability to promote cell growth and tissue regeneration. The review also discusses the modification and cross-linking of fibrin to enhance its mechanical strength, stability, and degradation rate, making it suitable for various tissue engineering applications.This review discusses the properties, modification, cross-linking, and applications of fibrin-based biomaterials in tissue engineering. Fibrin is a natural protein that forms a scaffold after tissue injury, offering high biocompatibility, non-toxicity, and low immunogenicity. It plays a critical role in cell adhesion, migration, proliferation, and wound healing. Fibrin scaffolds are widely used in tissue engineering to repair or enhance the function of damaged tissues and organs. The review covers the composition, structure, and biological properties of fibrin, as well as its modification and cross-linking methods. It also discusses various forms of fibrin used in tissue engineering, including fibrin hydrogels, fibrin glue, and fibrin microbeads. The review highlights the potential of fibrin scaffolds in applications such as skin, bone, and cardiac tissue regeneration. It also discusses the mechanical properties of fibrin, including its viscoelastic characteristics and strain-hardening behavior, which are important for tissue engineering applications. The degradation properties of fibrin are also discussed, as well as the changes in fibrin during tissue damage. The review concludes that fibrin scaffolds have significant potential in tissue engineering due to their biocompatibility, mechanical properties, and ability to promote cell growth and tissue regeneration. The review also discusses the modification and cross-linking of fibrin to enhance its mechanical strength, stability, and degradation rate, making it suitable for various tissue engineering applications.