PLGA hydrogels are widely used in biomedical research due to their biocompatibility, biodegradability, and versatility. This review discusses their synthesis, properties, sustained release mechanisms, and applications in drug delivery. PLGA hydrogels are effective for localized and sustained chemotherapy, antibiotic delivery, and tissue engineering. Challenges include improving drug loading efficiency and release control. Future research aims to optimize their efficacy and clinical applicability. PLGA hydrogels offer a promising platform for sustained therapeutic delivery, with potential to revolutionize drug delivery systems. The review highlights synthesis methods, including emulsion solvent evaporation, solvent casting, electrospinning, thermal gelation, and photopolymerization, and their role in tailoring hydrogel properties. Applications include drug delivery, tissue engineering, and wound healing. Challenges in PLGA hydrogel research include long-term controlled release and enhanced mechanical properties. The review emphasizes the importance of PLGA hydrogels in biomedical applications and their potential for future advancements.PLGA hydrogels are widely used in biomedical research due to their biocompatibility, biodegradability, and versatility. This review discusses their synthesis, properties, sustained release mechanisms, and applications in drug delivery. PLGA hydrogels are effective for localized and sustained chemotherapy, antibiotic delivery, and tissue engineering. Challenges include improving drug loading efficiency and release control. Future research aims to optimize their efficacy and clinical applicability. PLGA hydrogels offer a promising platform for sustained therapeutic delivery, with potential to revolutionize drug delivery systems. The review highlights synthesis methods, including emulsion solvent evaporation, solvent casting, electrospinning, thermal gelation, and photopolymerization, and their role in tailoring hydrogel properties. Applications include drug delivery, tissue engineering, and wound healing. Challenges in PLGA hydrogel research include long-term controlled release and enhanced mechanical properties. The review emphasizes the importance of PLGA hydrogels in biomedical applications and their potential for future advancements.