The article by Masten and Cicchetti explores the concept of *developmental cascades*, which refers to the cumulative and spreading effects of interactions and transactions within developing systems, influencing the course of ontogenesis and epigenesis. These effects can be direct, bidirectional, or indirect through various pathways, and they alter the trajectory of development. The authors highlight the importance of understanding these cascades in developmental psychopathology, as they can explain why some childhood problems predict widespread difficulties in adulthood. They also discuss the potential for interventions to interrupt negative cascades or promote positive ones, emphasizing the importance of early childhood interventions. The article reviews various models and methods used to test cascade effects, noting the challenges in longitudinal data collection and the need for sophisticated statistical approaches. It concludes by emphasizing the significance of developmental cascade research in informing theories of change and designing preventive interventions.The article by Masten and Cicchetti explores the concept of *developmental cascades*, which refers to the cumulative and spreading effects of interactions and transactions within developing systems, influencing the course of ontogenesis and epigenesis. These effects can be direct, bidirectional, or indirect through various pathways, and they alter the trajectory of development. The authors highlight the importance of understanding these cascades in developmental psychopathology, as they can explain why some childhood problems predict widespread difficulties in adulthood. They also discuss the potential for interventions to interrupt negative cascades or promote positive ones, emphasizing the importance of early childhood interventions. The article reviews various models and methods used to test cascade effects, noting the challenges in longitudinal data collection and the need for sophisticated statistical approaches. It concludes by emphasizing the significance of developmental cascade research in informing theories of change and designing preventive interventions.