The article by Peter G.H. Clarke, titled "Developmental cell death: morphological diversity and multiple mechanisms," focuses on the less explored aspect of how cells are dismantled during development. The review highlights three main morphological types of dying cells: "apoptotic," "autophagic," and "non-lysosomal vesiculate." These types reflect different intracellular events, primarily involving heterophagy, autophagy, and non-lysosomal degradation, respectively. The destruction of the cytoplasm in these types is achieved through these mechanisms. The article emphasizes the importance of considering the multiplicity of destructive mechanisms when studying other aspects of cell death, such as the signals that trigger it. The review also provides detailed descriptions of the nuclear and cytoplasmic destruction mechanisms and discusses the significance of these types in various developmental contexts.The article by Peter G.H. Clarke, titled "Developmental cell death: morphological diversity and multiple mechanisms," focuses on the less explored aspect of how cells are dismantled during development. The review highlights three main morphological types of dying cells: "apoptotic," "autophagic," and "non-lysosomal vesiculate." These types reflect different intracellular events, primarily involving heterophagy, autophagy, and non-lysosomal degradation, respectively. The destruction of the cytoplasm in these types is achieved through these mechanisms. The article emphasizes the importance of considering the multiplicity of destructive mechanisms when studying other aspects of cell death, such as the signals that trigger it. The review also provides detailed descriptions of the nuclear and cytoplasmic destruction mechanisms and discusses the significance of these types in various developmental contexts.