Diabetic Neuropathies: Update on Definitions, Diagnostic Criteria, Estimation of Severity, and Treatments

Diabetic Neuropathies: Update on Definitions, Diagnostic Criteria, Estimation of Severity, and Treatments

33:2285–2293, 2010 | Solomon Tesfaye, MD, FRCP1 Andrew J.M. Boulton, MD2 Peter J. Dyck, MD3 Roy Freeman, MD4 Michael Horowitz, MD, PhD5 Peter Kempler, MD, PhD6 Giuseppe Lauria, MD7 Rayaz A. Malik, MD2 Vincenza Spallone, MD, PhD8 Aaron Vinik, MD, PhD9 Luciano Bernardi, MD10 Paul Valensi, MD11 on behalf of the Toronto Diabetic Neuropathy Expert Group8
This article provides an updated overview of diabetic neuropathies, including definitions, diagnostic criteria, severity estimation, and treatments. The authors, representing the Toronto Diabetic Neuropathy Expert Group, discuss the classification and definition of diabetic neuropathies, distinguishing between typical and atypical diabetic sensorimotor polyneuropathy (DSPN) and autonomic neuropathy. They propose specific definitions for DSPN and atypical DPNs, emphasizing the importance of nerve conduction tests and other clinical assessments for diagnosis. The severity of DSPN is assessed through various measures, including neurological signs, symptoms, and functional abilities. The article also covers painful DPN, focusing on clinical diagnosis and management, and discusses diabetic autonomic neuropathy (DAN), particularly cardiovascular autonomic neuropathy (CAN), gastrointestinal autonomic neuropathy, erectile dysfunction, bladder dysfunction, and sudomotor dysfunction. Emerging markers of small fiber neuropathy, such as nerve biopsy, skin biopsy, corneal confocal microscopy, and nerve axon reflex/flare response, are reviewed. The authors conclude by highlighting the need for periodic updates in diagnostic criteria and the importance of ongoing research in the field.This article provides an updated overview of diabetic neuropathies, including definitions, diagnostic criteria, severity estimation, and treatments. The authors, representing the Toronto Diabetic Neuropathy Expert Group, discuss the classification and definition of diabetic neuropathies, distinguishing between typical and atypical diabetic sensorimotor polyneuropathy (DSPN) and autonomic neuropathy. They propose specific definitions for DSPN and atypical DPNs, emphasizing the importance of nerve conduction tests and other clinical assessments for diagnosis. The severity of DSPN is assessed through various measures, including neurological signs, symptoms, and functional abilities. The article also covers painful DPN, focusing on clinical diagnosis and management, and discusses diabetic autonomic neuropathy (DAN), particularly cardiovascular autonomic neuropathy (CAN), gastrointestinal autonomic neuropathy, erectile dysfunction, bladder dysfunction, and sudomotor dysfunction. Emerging markers of small fiber neuropathy, such as nerve biopsy, skin biopsy, corneal confocal microscopy, and nerve axon reflex/flare response, are reviewed. The authors conclude by highlighting the need for periodic updates in diagnostic criteria and the importance of ongoing research in the field.
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