29 February 2024 | Suneesh Thilak, Poppy Brown, Tony Whitehouse, Nandan Gautam, Errin Lawrence, Zubair Ahmed, Tonny Veenith
The article discusses the diagnosis and management of aneurysmal subarachnoid hemorrhage (aSAH), emphasizing the multisystem effects and the need for comprehensive multidisciplinary care. Advancements in computed tomography (CT), endovascular treatments, and neurocritical care have led to declining mortality rates. Critical care focuses on cerebral perfusion, early aneurysm securement, and preventing secondary brain injury and systemic complications. Standardized neurological assessments, advanced imaging, and hypertensive and invasive therapies are crucial. Health care disparities, particularly in resource allocation, affect outcomes, and telemedicine and novel technologies are proposed to address these inequalities. The article highlights the importance of early interventions to mitigate cardio-pulmonary complications, dyselectrolytemia, and treatment of the culprit aneurysm, emphasizing the need for large-scale studies to validate standardized treatment protocols. The pathophysiology of aSAH, including early brain injury (EBI) and delayed cerebral ischemia (DCI), is also discussed, along with the role of biomarkers and multimodality monitoring. The management of complications such as hydrocephalus, seizures, and DCI is addressed, along with the use of nimodipine and other therapeutic interventions. The article concludes by emphasizing the need for ongoing research and collaboration between neuroscientists, clinicians, and health policy experts to improve patient outcomes.The article discusses the diagnosis and management of aneurysmal subarachnoid hemorrhage (aSAH), emphasizing the multisystem effects and the need for comprehensive multidisciplinary care. Advancements in computed tomography (CT), endovascular treatments, and neurocritical care have led to declining mortality rates. Critical care focuses on cerebral perfusion, early aneurysm securement, and preventing secondary brain injury and systemic complications. Standardized neurological assessments, advanced imaging, and hypertensive and invasive therapies are crucial. Health care disparities, particularly in resource allocation, affect outcomes, and telemedicine and novel technologies are proposed to address these inequalities. The article highlights the importance of early interventions to mitigate cardio-pulmonary complications, dyselectrolytemia, and treatment of the culprit aneurysm, emphasizing the need for large-scale studies to validate standardized treatment protocols. The pathophysiology of aSAH, including early brain injury (EBI) and delayed cerebral ischemia (DCI), is also discussed, along with the role of biomarkers and multimodality monitoring. The management of complications such as hydrocephalus, seizures, and DCI is addressed, along with the use of nimodipine and other therapeutic interventions. The article concludes by emphasizing the need for ongoing research and collaboration between neuroscientists, clinicians, and health policy experts to improve patient outcomes.