This prospective study evaluates the accuracy of transient elastography (FibroScan) in detecting cirrhosis in patients with chronic liver disease. The study included 711 patients with various causes of chronic liver disease, including hepatitis C virus or hepatitis B virus infection, alcohol-related liver disease, non-alcoholic steatohepatitis, and others. Liver stiffness measurements ranged from 12.5 to 75.5 kPa, with significant correlation between stiffness and fibrosis stage (r=0.73, p=0.0001). The area under the receiver operating characteristic curve (AUROC) was 0.80 for significant fibrosis (F>2), 0.90 for severe fibrosis (F3), and 0.96 for cirrhosis. Using a cut-off value of 17.6 kPa, the positive predictive value and negative predictive value for detecting cirrhosis were 90%. Liver stiffness was also significantly correlated with clinical, biological, and morphological parameters of liver disease. The study concluded that transient elastography is a promising non-invasive method for detecting cirrhosis in patients with chronic liver disease and could be valuable for follow-up and management.This prospective study evaluates the accuracy of transient elastography (FibroScan) in detecting cirrhosis in patients with chronic liver disease. The study included 711 patients with various causes of chronic liver disease, including hepatitis C virus or hepatitis B virus infection, alcohol-related liver disease, non-alcoholic steatohepatitis, and others. Liver stiffness measurements ranged from 12.5 to 75.5 kPa, with significant correlation between stiffness and fibrosis stage (r=0.73, p=0.0001). The area under the receiver operating characteristic curve (AUROC) was 0.80 for significant fibrosis (F>2), 0.90 for severe fibrosis (F3), and 0.96 for cirrhosis. Using a cut-off value of 17.6 kPa, the positive predictive value and negative predictive value for detecting cirrhosis were 90%. Liver stiffness was also significantly correlated with clinical, biological, and morphological parameters of liver disease. The study concluded that transient elastography is a promising non-invasive method for detecting cirrhosis in patients with chronic liver disease and could be valuable for follow-up and management.