The article by Jon M. Hanifin and Georg Rajka discusses the diagnostic features of atopic dermatitis, emphasizing the need for clear guidelines to distinguish it from other skin conditions. The authors highlight that there is no objective laboratory marker for atopic dermatitis, and the terminology varies across specialties and countries. They propose a unified set of diagnostic criteria, which include at least three basic features: pruritus, lichenification, and a chronically relapsing course. Additionally, patients should exhibit three or more minor features, such as xerosis, ichthyosis, immediate skin test reactivity, elevated serum IgE, and early age of onset. The article also addresses the challenges in diagnosing atopic dermatitis, particularly in distinguishing it from other conditions like hyperimmunoglobulinemia-E syndrome. The authors emphasize the importance of uniform criteria for diagnosing atopic dermatitis, especially for non-dermatologists, and provide a comprehensive list of both basic and minor features to aid in the diagnosis.The article by Jon M. Hanifin and Georg Rajka discusses the diagnostic features of atopic dermatitis, emphasizing the need for clear guidelines to distinguish it from other skin conditions. The authors highlight that there is no objective laboratory marker for atopic dermatitis, and the terminology varies across specialties and countries. They propose a unified set of diagnostic criteria, which include at least three basic features: pruritus, lichenification, and a chronically relapsing course. Additionally, patients should exhibit three or more minor features, such as xerosis, ichthyosis, immediate skin test reactivity, elevated serum IgE, and early age of onset. The article also addresses the challenges in diagnosing atopic dermatitis, particularly in distinguishing it from other conditions like hyperimmunoglobulinemia-E syndrome. The authors emphasize the importance of uniform criteria for diagnosing atopic dermatitis, especially for non-dermatologists, and provide a comprehensive list of both basic and minor features to aid in the diagnosis.