2024 | Sandeep Samethadka Nayak, Dona Kuriyakose, Lakshmi D. Polisetty, Anjali Avinash Patil, Daniyal Ameen, Rakshita Bonu, Samatha P. Shetty, Pubali Biswas, Micheal T. Ulrich, Negin Letafatkar, Arman Habibi, Mohammad-Hossein Keivanlou, Sara Nobakht, Abdulhadi Alotaibi, Soheil Hassanipour, Ehsan Amini-Salehi
This umbrella review aims to collate and summarize the findings from previous meta-analyses on the Triglyceride and Glucose (TyG) Index, providing insights to clinicians, researchers, and policymakers regarding its usefulness in various clinical settings. A comprehensive search was conducted in PubMed, Scopus, and Web of Science up to April 14, 2024, without language restrictions. The AMSTAR2 checklist was used to assess the methodological quality of the included meta-analyses, and statistical analyses were performed using Comprehensive Meta-Analysis (CMA) software.
A total of 32 studies were included, covering a wide range of medical conditions. The results revealed significant associations between the TyG index and various health outcomes. For kidney outcomes, a high TyG index was significantly associated with an increased risk of contrast-induced nephropathy (CIN) and chronic kidney disease (CKD). For metabolic diseases, the TyG index was significantly higher in patients with obstructive sleep apnea (OSA), metabolic syndrome, and non-alcoholic fatty liver disease (NAFLD). Regarding cerebrovascular diseases, a higher TyG index was significantly associated with an increased risk of dementia, cognitive impairment, and ischemic stroke. For cardiovascular outcomes, the TyG index showed significant associations with an increased risk of heart failure (HF), atrial fibrillation (AF), and hypertension (HTN).
The review concluded that the TyG index is a promising biomarker for screening and predicting various medical conditions, particularly those related to insulin resistance and metabolic disorders. However, the heterogeneity and methodological quality of the included studies suggest the need for further high-quality research to confirm these findings and refine the clinical utility of the TyG index.This umbrella review aims to collate and summarize the findings from previous meta-analyses on the Triglyceride and Glucose (TyG) Index, providing insights to clinicians, researchers, and policymakers regarding its usefulness in various clinical settings. A comprehensive search was conducted in PubMed, Scopus, and Web of Science up to April 14, 2024, without language restrictions. The AMSTAR2 checklist was used to assess the methodological quality of the included meta-analyses, and statistical analyses were performed using Comprehensive Meta-Analysis (CMA) software.
A total of 32 studies were included, covering a wide range of medical conditions. The results revealed significant associations between the TyG index and various health outcomes. For kidney outcomes, a high TyG index was significantly associated with an increased risk of contrast-induced nephropathy (CIN) and chronic kidney disease (CKD). For metabolic diseases, the TyG index was significantly higher in patients with obstructive sleep apnea (OSA), metabolic syndrome, and non-alcoholic fatty liver disease (NAFLD). Regarding cerebrovascular diseases, a higher TyG index was significantly associated with an increased risk of dementia, cognitive impairment, and ischemic stroke. For cardiovascular outcomes, the TyG index showed significant associations with an increased risk of heart failure (HF), atrial fibrillation (AF), and hypertension (HTN).
The review concluded that the TyG index is a promising biomarker for screening and predicting various medical conditions, particularly those related to insulin resistance and metabolic disorders. However, the heterogeneity and methodological quality of the included studies suggest the need for further high-quality research to confirm these findings and refine the clinical utility of the TyG index.