This review provides a comprehensive guide to the use of dialkylbiaryl phosphines as ligands in Pd-catalyzed amination reactions. These ligands have been widely applied in the synthesis of biologically active molecules due to their versatility and efficiency. The review covers key reaction parameters such as ligand choice, catalyst activation, solvent selection, and base choice, highlighting their impact on substrate compatibility and reaction outcomes. It also discusses the challenges and advantages of using different types of electrophiles and nucleophiles, including aryl halides, heteroaryls, anilines, aliphatic amines, amides, and NH heterocycles. The review emphasizes the importance of optimizing these parameters to achieve the best reaction conditions for specific substrate combinations, providing practical insights for researchers in the field.This review provides a comprehensive guide to the use of dialkylbiaryl phosphines as ligands in Pd-catalyzed amination reactions. These ligands have been widely applied in the synthesis of biologically active molecules due to their versatility and efficiency. The review covers key reaction parameters such as ligand choice, catalyst activation, solvent selection, and base choice, highlighting their impact on substrate compatibility and reaction outcomes. It also discusses the challenges and advantages of using different types of electrophiles and nucleophiles, including aryl halides, heteroaryls, anilines, aliphatic amines, amides, and NH heterocycles. The review emphasizes the importance of optimizing these parameters to achieve the best reaction conditions for specific substrate combinations, providing practical insights for researchers in the field.