A study published in JAMA Network Open examined the relationship between dietary niacin intake and mortality risk in individuals with nonalcoholic fatty liver disease (NAFLD). The research used data from the National Health and Nutrition Examination Survey (NHANES) spanning 2003-2018, analyzing 4315 adults with NAFLD. The study found that higher dietary niacin intake was associated with a lower risk of all-cause mortality, but no significant inverse association was found with cardiovascular disease (CVD) mortality. Participants with the highest niacin intake (≥26.7 mg) had a 30% lower risk of all-cause mortality compared to those with the lowest intake (≤18.4 mg). However, after adjusting for multiple confounders, no significant association was found between niacin intake and CVD mortality. The study also found that niacin intake was inversely associated with all-cause mortality in subgroups with diabetes and low vitamin B6 levels. The findings suggest that increased dietary niacin intake may benefit individuals with NAFLD, although further research is needed to confirm the association with CVD mortality. The study had limitations, including potential recall bias and the inability to establish causality. The results highlight the importance of niacin in liver health and its potential role in reducing mortality risk in NAFLD patients.A study published in JAMA Network Open examined the relationship between dietary niacin intake and mortality risk in individuals with nonalcoholic fatty liver disease (NAFLD). The research used data from the National Health and Nutrition Examination Survey (NHANES) spanning 2003-2018, analyzing 4315 adults with NAFLD. The study found that higher dietary niacin intake was associated with a lower risk of all-cause mortality, but no significant inverse association was found with cardiovascular disease (CVD) mortality. Participants with the highest niacin intake (≥26.7 mg) had a 30% lower risk of all-cause mortality compared to those with the lowest intake (≤18.4 mg). However, after adjusting for multiple confounders, no significant association was found between niacin intake and CVD mortality. The study also found that niacin intake was inversely associated with all-cause mortality in subgroups with diabetes and low vitamin B6 levels. The findings suggest that increased dietary niacin intake may benefit individuals with NAFLD, although further research is needed to confirm the association with CVD mortality. The study had limitations, including potential recall bias and the inability to establish causality. The results highlight the importance of niacin in liver health and its potential role in reducing mortality risk in NAFLD patients.