This systematic review evaluates the comparative advantages of digital impression techniques over conventional techniques in prosthodontics. The study aimed to assess the accuracy, patient acceptability, operator preference, and time effectiveness of digital impressions. A comprehensive literature review was conducted using the PICO framework, searching electronic databases from 2000 to 2025. The review included both clinical and preclinical studies, as well as randomized controlled trials. The results indicate that digital impressions exhibit comparable accuracy to conventional impressions, with no statistically significant differences in marginal gaps, which are considered clinically acceptable. Digital impressions offer several advantages, including increased accuracy, reduced patient discomfort, faster turnaround times, improved communication between dentists and technicians, and enhanced patient education and treatment planning. However, the initial cost of acquiring digital equipment and software is a significant challenge. Despite this, digital impressions can save costs in the long run by eliminating the need for traditional impression materials and reducing the number of patient visits. Patient satisfaction and comfort levels are higher with digital impressions, and they provide greater time efficiency and operator convenience. The review concludes that digital impressions and CAD/CAM have revolutionized prosthodontics, improving accuracy, predictability, and efficiency in dental practices.This systematic review evaluates the comparative advantages of digital impression techniques over conventional techniques in prosthodontics. The study aimed to assess the accuracy, patient acceptability, operator preference, and time effectiveness of digital impressions. A comprehensive literature review was conducted using the PICO framework, searching electronic databases from 2000 to 2025. The review included both clinical and preclinical studies, as well as randomized controlled trials. The results indicate that digital impressions exhibit comparable accuracy to conventional impressions, with no statistically significant differences in marginal gaps, which are considered clinically acceptable. Digital impressions offer several advantages, including increased accuracy, reduced patient discomfort, faster turnaround times, improved communication between dentists and technicians, and enhanced patient education and treatment planning. However, the initial cost of acquiring digital equipment and software is a significant challenge. Despite this, digital impressions can save costs in the long run by eliminating the need for traditional impression materials and reducing the number of patient visits. Patient satisfaction and comfort levels are higher with digital impressions, and they provide greater time efficiency and operator convenience. The review concludes that digital impressions and CAD/CAM have revolutionized prosthodontics, improving accuracy, predictability, and efficiency in dental practices.