This study introduces a spatiotemporal on-demand patch (SOP) for transdermal drug delivery, which integrates drug-loaded microneedles with biocompatible metallic membranes to enable electrically triggered active control of drug release. The SOP features precise control of drug release to targeted locations (<1 mm²), rapid drug release response to electrical triggers (<30 s), and multimodal operation involving both drug release and electrical stimulation. The solution-based fabrication method ensures high customizability and scalability, making it suitable for various pharmaceutical needs. The wireless-powered and digital-controlled SOP demonstrates great promise in achieving full automation of drug delivery, improving user adherence while ensuring medical precision. In vivo studies using intracranial injection of SOPs reveal their potential utility in neural therapy and modulation, particularly in studying neural circuits and the cause-and-effect relationships between neural activity and behavior. The SOP's ability to deliver therapeutic agents sequentially and proactively to specific brain regions associated with neurological disorders may deepen our understanding of underlying mechanisms and lead to more targeted treatments for disorders like Parkinson's disease, epilepsy, depression, and Alzheimer's disease.This study introduces a spatiotemporal on-demand patch (SOP) for transdermal drug delivery, which integrates drug-loaded microneedles with biocompatible metallic membranes to enable electrically triggered active control of drug release. The SOP features precise control of drug release to targeted locations (<1 mm²), rapid drug release response to electrical triggers (<30 s), and multimodal operation involving both drug release and electrical stimulation. The solution-based fabrication method ensures high customizability and scalability, making it suitable for various pharmaceutical needs. The wireless-powered and digital-controlled SOP demonstrates great promise in achieving full automation of drug delivery, improving user adherence while ensuring medical precision. In vivo studies using intracranial injection of SOPs reveal their potential utility in neural therapy and modulation, particularly in studying neural circuits and the cause-and-effect relationships between neural activity and behavior. The SOP's ability to deliver therapeutic agents sequentially and proactively to specific brain regions associated with neurological disorders may deepen our understanding of underlying mechanisms and lead to more targeted treatments for disorders like Parkinson's disease, epilepsy, depression, and Alzheimer's disease.