The paper discusses the potential of electrowetting-on-dielectric (EWD) microfluidics for true lab-on-a-chip applications. It highlights the need for a hierarchical design approach to manage the diversity of biomedical applications, breaking them down into manageable components and assembling them into a reconfigurable and reusable architecture. The author emphasizes the importance of standard commercial components and the development of a complete set of elemental fluidic components to support all required fluidic operations. The paper also explores the advantages of EWD technology, such as the ability to program different fluidic functions on a common platform, and discusses the current status of the EWD toolkit. The goal is to establish a development path for microfluidics that is similar to the development of digital electronics, enabling the creation of versatile and scalable microfluidic devices for a wide range of applications.The paper discusses the potential of electrowetting-on-dielectric (EWD) microfluidics for true lab-on-a-chip applications. It highlights the need for a hierarchical design approach to manage the diversity of biomedical applications, breaking them down into manageable components and assembling them into a reconfigurable and reusable architecture. The author emphasizes the importance of standard commercial components and the development of a complete set of elemental fluidic components to support all required fluidic operations. The paper also explores the advantages of EWD technology, such as the ability to program different fluidic functions on a common platform, and discusses the current status of the EWD toolkit. The goal is to establish a development path for microfluidics that is similar to the development of digital electronics, enabling the creation of versatile and scalable microfluidic devices for a wide range of applications.