This paper presents a novel approach for ultrathin, conformal bio-integrated electronics using dissolvable silk fibroin films. The system utilizes ultrathin electronics supported by bioresorbable silk fibroin substrates, which dissolve and resorb, enabling spontaneous, conformal wrapping of the device on biological tissues. The design ensures minimal stress on the tissue and high conformal coverage, even on complex curvilinear surfaces. The silk fibroin is biocompatible, bioresorbable, and water-soluble with programmable dissolution rates. The electronics are fabricated on silk substrates and then transferred to the silk film for integration with separately fabricated electronics. The system is designed for use in brain-computer interfaces (BCIs) and other biomedical applications where conformal contact with biological tissues is essential. The silk-based substrates allow for the fabrication of ultrathin, flexible, and conformable electrode arrays that can be implanted into the brain. The arrays are designed to minimize tissue damage and provide long-term electrical interface stability. The study demonstrates the effectiveness of the system in in vivo neural mapping experiments on feline animal models. The results show that the system provides improved conformal contact and electrical signal quality compared to conventional electrode arrays. The study also highlights the potential of this technology for a wide range of biomedical applications, including implantable or surgical devices. The fabrication process involves the use of silk fibroin derived from Bombyx mori cocoons, followed by chemical treatments and spin casting to create ultrathin films. The electronics are then transferred to the silk film and connected to an anisotropic conductive film (ACF) for electrical connection. The system is tested in animal experiments, demonstrating its ability to provide high-quality neural signals and conformal contact with the brain. The study also provides insights into the mechanics of conformal contact and the factors that influence the performance of the system. The results show that the system can achieve conformal contact on complex surfaces, such as the brain, with minimal mechanical stress. The study concludes that the silk-based bio-integrated electronics offer a promising solution for the development of implantable or surgical devices that can provide long-term, stable electrical interface with biological tissues.This paper presents a novel approach for ultrathin, conformal bio-integrated electronics using dissolvable silk fibroin films. The system utilizes ultrathin electronics supported by bioresorbable silk fibroin substrates, which dissolve and resorb, enabling spontaneous, conformal wrapping of the device on biological tissues. The design ensures minimal stress on the tissue and high conformal coverage, even on complex curvilinear surfaces. The silk fibroin is biocompatible, bioresorbable, and water-soluble with programmable dissolution rates. The electronics are fabricated on silk substrates and then transferred to the silk film for integration with separately fabricated electronics. The system is designed for use in brain-computer interfaces (BCIs) and other biomedical applications where conformal contact with biological tissues is essential. The silk-based substrates allow for the fabrication of ultrathin, flexible, and conformable electrode arrays that can be implanted into the brain. The arrays are designed to minimize tissue damage and provide long-term electrical interface stability. The study demonstrates the effectiveness of the system in in vivo neural mapping experiments on feline animal models. The results show that the system provides improved conformal contact and electrical signal quality compared to conventional electrode arrays. The study also highlights the potential of this technology for a wide range of biomedical applications, including implantable or surgical devices. The fabrication process involves the use of silk fibroin derived from Bombyx mori cocoons, followed by chemical treatments and spin casting to create ultrathin films. The electronics are then transferred to the silk film and connected to an anisotropic conductive film (ACF) for electrical connection. The system is tested in animal experiments, demonstrating its ability to provide high-quality neural signals and conformal contact with the brain. The study also provides insights into the mechanics of conformal contact and the factors that influence the performance of the system. The results show that the system can achieve conformal contact on complex surfaces, such as the brain, with minimal mechanical stress. The study concludes that the silk-based bio-integrated electronics offer a promising solution for the development of implantable or surgical devices that can provide long-term, stable electrical interface with biological tissues.