This study aims to explore the relationship between comorbidities and the risk of COVID-19 patients. A meta-analysis was conducted using data from six retrospective studies involving 1,558 patients with COVID-19. The analysis identified hypertension, diabetes, chronic obstructive pulmonary disease (COPD), cardiovascular disease, and cerebrovascular disease as significant risk factors for severe COVID-19. Specifically, patients with hypertension had a 2.29-fold increased risk (OR: 2.29, P<0.001), diabetes had a 2.47-fold increased risk (OR: 2.47, P<0.001), COPD had a 5.97-fold increased risk (OR: 5.97, P<0.001), cardiovascular disease had a 2.93-fold increased risk (OR: 2.93, P<0.001), and cerebrovascular disease had a 3.89-fold increased risk (OR: 3.89, P=0.002). However, no significant correlation was found between liver disease, malignancy, or renal disease and the risk of COVID-19 progression. The study concludes that understanding these risk factors can help clinicians manage COVID-19 patients more effectively.This study aims to explore the relationship between comorbidities and the risk of COVID-19 patients. A meta-analysis was conducted using data from six retrospective studies involving 1,558 patients with COVID-19. The analysis identified hypertension, diabetes, chronic obstructive pulmonary disease (COPD), cardiovascular disease, and cerebrovascular disease as significant risk factors for severe COVID-19. Specifically, patients with hypertension had a 2.29-fold increased risk (OR: 2.29, P<0.001), diabetes had a 2.47-fold increased risk (OR: 2.47, P<0.001), COPD had a 5.97-fold increased risk (OR: 5.97, P<0.001), cardiovascular disease had a 2.93-fold increased risk (OR: 2.93, P<0.001), and cerebrovascular disease had a 3.89-fold increased risk (OR: 3.89, P=0.002). However, no significant correlation was found between liver disease, malignancy, or renal disease and the risk of COVID-19 progression. The study concludes that understanding these risk factors can help clinicians manage COVID-19 patients more effectively.