This study examines the influence of education on COVID-19 vaccination rates globally, focusing on 45 low-income countries (LICs), 72 middle-income countries (MICs), and 53 high-income countries (HICs). The research employs statistical methods to analyze the relationship between educational levels (primary, secondary, and tertiary) and vaccination rates, considering various socio-economic factors such as GDP per capita, elderly population, comorbidities, and stringency index. The findings suggest that education significantly impacts vaccination rates, with tertiary education having the strongest positive correlation. Higher education levels are associated with higher vaccination rates, particularly in HICs. The study also highlights the importance of targeted educational interventions, especially in LICs and MICs, to enhance vaccine acceptance and improve health outcomes. The results emphasize the need for health authorities to engage in ongoing dialogue with all population groups, especially vulnerable communities, to address vaccine hesitancy and promote informed decision-making.This study examines the influence of education on COVID-19 vaccination rates globally, focusing on 45 low-income countries (LICs), 72 middle-income countries (MICs), and 53 high-income countries (HICs). The research employs statistical methods to analyze the relationship between educational levels (primary, secondary, and tertiary) and vaccination rates, considering various socio-economic factors such as GDP per capita, elderly population, comorbidities, and stringency index. The findings suggest that education significantly impacts vaccination rates, with tertiary education having the strongest positive correlation. Higher education levels are associated with higher vaccination rates, particularly in HICs. The study also highlights the importance of targeted educational interventions, especially in LICs and MICs, to enhance vaccine acceptance and improve health outcomes. The results emphasize the need for health authorities to engage in ongoing dialogue with all population groups, especially vulnerable communities, to address vaccine hesitancy and promote informed decision-making.