This study investigates the relationship between education levels (primary, secondary, tertiary) and COVID-19 vaccination rates across 45 low-income countries (LICs), 72 middle-income countries (MICs), and 53 high-income countries (HICs). The findings indicate that education significantly influences vaccination rates, with tertiary education having the strongest impact. HICs generally exhibit higher vaccination rates, while LICs show more variability. The study highlights that higher education levels are associated with greater vaccination acceptance, as educated individuals are more aware of the benefits of vaccination and more likely to trust health information. However, in LICs, where education levels are lower, vaccination rates are also lower, often due to limited access to information and resources. The study recommends that public health strategies should focus on improving education and increasing awareness about vaccination, particularly in vulnerable communities. It also emphasizes the importance of targeted communication and education campaigns to address vaccine hesitancy and improve vaccination coverage. Overall, education plays a crucial role in shaping vaccination behaviors, and improving educational outcomes can lead to better public health outcomes.This study investigates the relationship between education levels (primary, secondary, tertiary) and COVID-19 vaccination rates across 45 low-income countries (LICs), 72 middle-income countries (MICs), and 53 high-income countries (HICs). The findings indicate that education significantly influences vaccination rates, with tertiary education having the strongest impact. HICs generally exhibit higher vaccination rates, while LICs show more variability. The study highlights that higher education levels are associated with greater vaccination acceptance, as educated individuals are more aware of the benefits of vaccination and more likely to trust health information. However, in LICs, where education levels are lower, vaccination rates are also lower, often due to limited access to information and resources. The study recommends that public health strategies should focus on improving education and increasing awareness about vaccination, particularly in vulnerable communities. It also emphasizes the importance of targeted communication and education campaigns to address vaccine hesitancy and improve vaccination coverage. Overall, education plays a crucial role in shaping vaccination behaviors, and improving educational outcomes can lead to better public health outcomes.