Dopamine D1–D5 receptors in brain nuclei play critical roles in health and disease, influencing movement, cognition, motivation, and reward. This review explores the distribution, physiological significance, and disease relevance of these receptors in distinct brain regions. Dopamine receptors are widely distributed across the brain, with specific subtypes localized in regions such as the striatum, nucleus accumbens, substantia nigra, and limbic system. Genetic variations in these receptors are linked to disorders like schizophrenia, Parkinson's disease, and addiction. The review highlights the distinct functions of D1, D2, D3, D4, and D5 receptors in various brain nuclei, emphasizing their roles in motor control, reward processing, emotional regulation, and cognitive functions. Dysregulation of these receptors contributes to neurodegenerative and psychiatric conditions. Dopamine receptor imaging techniques, such as PET and SPECT, provide insights into receptor density and occupancy in neurological and psychiatric disorders. The review also discusses the impact of dopamine receptors in key brain regions like the striatum, prefrontal cortex, subthalamic nucleus, amygdala, and hippocampus, highlighting their involvement in motor control, reward, motivation, and cognitive processes. Understanding the complex interactions of dopamine receptors in these regions is essential for developing targeted therapeutic strategies to address aging-related and mental health challenges. The review underscores the importance of dopamine receptors in maintaining neurological health and their potential as therapeutic targets for various disorders.Dopamine D1–D5 receptors in brain nuclei play critical roles in health and disease, influencing movement, cognition, motivation, and reward. This review explores the distribution, physiological significance, and disease relevance of these receptors in distinct brain regions. Dopamine receptors are widely distributed across the brain, with specific subtypes localized in regions such as the striatum, nucleus accumbens, substantia nigra, and limbic system. Genetic variations in these receptors are linked to disorders like schizophrenia, Parkinson's disease, and addiction. The review highlights the distinct functions of D1, D2, D3, D4, and D5 receptors in various brain nuclei, emphasizing their roles in motor control, reward processing, emotional regulation, and cognitive functions. Dysregulation of these receptors contributes to neurodegenerative and psychiatric conditions. Dopamine receptor imaging techniques, such as PET and SPECT, provide insights into receptor density and occupancy in neurological and psychiatric disorders. The review also discusses the impact of dopamine receptors in key brain regions like the striatum, prefrontal cortex, subthalamic nucleus, amygdala, and hippocampus, highlighting their involvement in motor control, reward, motivation, and cognitive processes. Understanding the complex interactions of dopamine receptors in these regions is essential for developing targeted therapeutic strategies to address aging-related and mental health challenges. The review underscores the importance of dopamine receptors in maintaining neurological health and their potential as therapeutic targets for various disorders.