The article "Drug Solubility: Importance and Enhancement Techniques" by Ketan T. Savjani, Anuradha K. Gajjar, and Jignasa K. Savjani discusses the significance of solubility in drug formulation and the various techniques used to enhance it. Solubility, the ability of a solute to dissolve in a solvent, is crucial for achieving the desired concentration of drugs in systemic circulation. Low aqueous solubility is a significant challenge in the development of new chemical entities (NCEs) and generic drugs, affecting oral bioavailability and patient compliance. The article outlines several methods to improve solubility, including physical modifications (such as particle size reduction, crystal engineering, and solid dispersion), chemical modifications (like salt formation and complexation), and miscellaneous methods (such as supercritical fluid processes and surfactant use). Each technique is evaluated based on its advantages, limitations, and suitability for different drug properties and dosage forms. The article emphasizes the importance of selecting the appropriate solubility enhancement method to ensure good oral bioavailability, reduce dosing frequency, and improve patient compliance while maintaining cost-effectiveness.The article "Drug Solubility: Importance and Enhancement Techniques" by Ketan T. Savjani, Anuradha K. Gajjar, and Jignasa K. Savjani discusses the significance of solubility in drug formulation and the various techniques used to enhance it. Solubility, the ability of a solute to dissolve in a solvent, is crucial for achieving the desired concentration of drugs in systemic circulation. Low aqueous solubility is a significant challenge in the development of new chemical entities (NCEs) and generic drugs, affecting oral bioavailability and patient compliance. The article outlines several methods to improve solubility, including physical modifications (such as particle size reduction, crystal engineering, and solid dispersion), chemical modifications (like salt formation and complexation), and miscellaneous methods (such as supercritical fluid processes and surfactant use). Each technique is evaluated based on its advantages, limitations, and suitability for different drug properties and dosage forms. The article emphasizes the importance of selecting the appropriate solubility enhancement method to ensure good oral bioavailability, reduce dosing frequency, and improve patient compliance while maintaining cost-effectiveness.