This article presents a method for dynamic, high-resolution imaging of cerebral blood flow (CBF) using laser speckle. By illuminating the cortex with laser light and imaging the resulting speckle pattern, relative CBF images with tens of microns spatial and millisecond temporal resolution are obtained. The regional CBF changes measured with the speckle technique are validated through direct comparison with conventional laser-Doppler measurements. The method is applied to study focal cerebral ischemia and cortical spreading depression, providing high-resolution images of residual CBF gradients and dynamic changes in CBF during these events. The speckle technique is easy to implement and can be used to monitor the spatial and temporal evolution of CBF changes in studies of cerebral pathophysiology.This article presents a method for dynamic, high-resolution imaging of cerebral blood flow (CBF) using laser speckle. By illuminating the cortex with laser light and imaging the resulting speckle pattern, relative CBF images with tens of microns spatial and millisecond temporal resolution are obtained. The regional CBF changes measured with the speckle technique are validated through direct comparison with conventional laser-Doppler measurements. The method is applied to study focal cerebral ischemia and cortical spreading depression, providing high-resolution images of residual CBF gradients and dynamic changes in CBF during these events. The speckle technique is easy to implement and can be used to monitor the spatial and temporal evolution of CBF changes in studies of cerebral pathophysiology.