The article discusses the development and optimization of dynamic carriers for therapeutic RNA delivery, emphasizing the importance of both chemical and biological design. RNA carriers must stabilize and protect therapeutic RNA during delivery to target tissues and across cellular membranes, then release the cargo in a bioactive form. The chemical space of carriers includes small cationic lipids, medium-sized sequence-defined xenopeptides, and macromolecular poly-lations. The authors highlight the discovery of virus-inspired dynamic processes that capitalize on mutual nanoparticle-host interactions to achieve potent RNA delivery. These processes involve subtle alterations in pH, ion concentration, redox potential, and the presence of specific proteins, receptors, or enzymes, which are recognized by the RNA nanocarrier via dynamic chemical designs. The article reviews current RNA carriers based on cationic lipids, polymers, and sequence-defined xenopeptides, emphasizing the importance of dynamic (supra)molecular design to meet the challenges of efficient RNA delivery. It discusses the evolution of liposomal therapeutics over 60 years, from initial lipoplexes to lipid nanoparticles (LNPs), and the role of cationic lipids, cholesterol, and polyethylene glycol (PEG)-lipids in enhancing RNA encapsulation and delivery. The authors also explore the design of dynamic polypelexes and polymer micelleplexes, which can effectively package polyanionic nucleic acids into compact, protected forms. The article concludes by discussing future steps and challenges in RNA delivery, including the need for robust chemistry and stable storage, addressing the discrepancy between in vitro and in vivo efficacy, and leveraging bioinspired chemical evolution and machine learning to develop more effective RNA carriers. The authors emphasize the potential of lipid-polymer combinations for targeting tissues beyond the liver and the importance of further optimization of nonviral, synthetic delivery systems.The article discusses the development and optimization of dynamic carriers for therapeutic RNA delivery, emphasizing the importance of both chemical and biological design. RNA carriers must stabilize and protect therapeutic RNA during delivery to target tissues and across cellular membranes, then release the cargo in a bioactive form. The chemical space of carriers includes small cationic lipids, medium-sized sequence-defined xenopeptides, and macromolecular poly-lations. The authors highlight the discovery of virus-inspired dynamic processes that capitalize on mutual nanoparticle-host interactions to achieve potent RNA delivery. These processes involve subtle alterations in pH, ion concentration, redox potential, and the presence of specific proteins, receptors, or enzymes, which are recognized by the RNA nanocarrier via dynamic chemical designs. The article reviews current RNA carriers based on cationic lipids, polymers, and sequence-defined xenopeptides, emphasizing the importance of dynamic (supra)molecular design to meet the challenges of efficient RNA delivery. It discusses the evolution of liposomal therapeutics over 60 years, from initial lipoplexes to lipid nanoparticles (LNPs), and the role of cationic lipids, cholesterol, and polyethylene glycol (PEG)-lipids in enhancing RNA encapsulation and delivery. The authors also explore the design of dynamic polypelexes and polymer micelleplexes, which can effectively package polyanionic nucleic acids into compact, protected forms. The article concludes by discussing future steps and challenges in RNA delivery, including the need for robust chemistry and stable storage, addressing the discrepancy between in vitro and in vivo efficacy, and leveraging bioinspired chemical evolution and machine learning to develop more effective RNA carriers. The authors emphasize the potential of lipid-polymer combinations for targeting tissues beyond the liver and the importance of further optimization of nonviral, synthetic delivery systems.