The article discusses the dynamic molecular processes that mediate cellular mechanotransduction, which is crucial for various physiological and pathological processes. Mechanotransduction involves the conversion of mechanical forces into biochemical signals, and recent studies have shown that sub-cellular structures such as the plasma membrane, cell adhesions, and the cytoskeleton undergo dynamic changes in response to applied forces. These dynamic processes help explain how different strengths and characteristics of forces regulate distinct signaling pathways. The authors highlight the importance of mechanical factors, such as applied forces and extracellular matrix (ECM) rigidity, in influencing cell and tissue function. They emphasize that mechanotransduction is not a simple switch-like process but involves a series of rapid events that lead to cellular responses. The article outlines the basic features of mechanotransduction, including mechanotransmission, mechanosensing, and mechanoresponse, and discusses the limitations of switch-like models. Recent advances in understanding the dynamic processes regulating load-bearing subcellular structures and the behavior of single molecules in response to applied forces are described. These studies reveal that the dynamic nature of cytoskeletal protein-protein bonds directly leads to viscoelastic effects, which can enable certain frequencies of mechanical stimuli to be selectively transmitted over greater distances in cells. The article also explores how single molecules or pairs of molecules respond to dynamic forces, and how these molecular processes are integrated to mediate complex phenomena like mechanotransduction. It proposes a dynamic model of mechanotransduction that integrates mechanotransmission, mechanosensing, and mechanoresponse, suggesting that cells may function as multi-bandpass filters, selectively transmitting specific frequencies of mechanical stimuli. Finally, the authors discuss the implications of these findings for understanding how cells sense and respond to dynamic mechanical stimuli, and suggest that mechanical forces can play subtle and precise roles in governing morphogenesis, physiology, and disease.The article discusses the dynamic molecular processes that mediate cellular mechanotransduction, which is crucial for various physiological and pathological processes. Mechanotransduction involves the conversion of mechanical forces into biochemical signals, and recent studies have shown that sub-cellular structures such as the plasma membrane, cell adhesions, and the cytoskeleton undergo dynamic changes in response to applied forces. These dynamic processes help explain how different strengths and characteristics of forces regulate distinct signaling pathways. The authors highlight the importance of mechanical factors, such as applied forces and extracellular matrix (ECM) rigidity, in influencing cell and tissue function. They emphasize that mechanotransduction is not a simple switch-like process but involves a series of rapid events that lead to cellular responses. The article outlines the basic features of mechanotransduction, including mechanotransmission, mechanosensing, and mechanoresponse, and discusses the limitations of switch-like models. Recent advances in understanding the dynamic processes regulating load-bearing subcellular structures and the behavior of single molecules in response to applied forces are described. These studies reveal that the dynamic nature of cytoskeletal protein-protein bonds directly leads to viscoelastic effects, which can enable certain frequencies of mechanical stimuli to be selectively transmitted over greater distances in cells. The article also explores how single molecules or pairs of molecules respond to dynamic forces, and how these molecular processes are integrated to mediate complex phenomena like mechanotransduction. It proposes a dynamic model of mechanotransduction that integrates mechanotransmission, mechanosensing, and mechanoresponse, suggesting that cells may function as multi-bandpass filters, selectively transmitting specific frequencies of mechanical stimuli. Finally, the authors discuss the implications of these findings for understanding how cells sense and respond to dynamic mechanical stimuli, and suggest that mechanical forces can play subtle and precise roles in governing morphogenesis, physiology, and disease.