The study introduces a miniature, self-powered biomimetic trinity triboelectric nanogenerator (TRI-TENG) cardiac patch that integrates energy harvesting, therapeutics, and diagnosis. This patch, designed to repair infarcted myocardium, features a unique double-spacer structure that enhances electroactivity and enables wireless monitoring of electrocardiogram signals. The TRI-TENG patch uses a polydopamine (PDA)-modified reduced graphene oxide (rGO) membrane as a therapeutic electrode, converting biomechanical energy into electrical energy and monitoring cardiac activity. In vitro and in vivo tests demonstrate the patch's effectiveness in improving cardiac function, reducing fibrosis, and enhancing electrical conduction in rat and minipig models of myocardial infarction. The TRI-TENG patch shows superior performance compared to traditional conductive cardiac patches, making it a promising tool for cardiac repair and remote monitoring.The study introduces a miniature, self-powered biomimetic trinity triboelectric nanogenerator (TRI-TENG) cardiac patch that integrates energy harvesting, therapeutics, and diagnosis. This patch, designed to repair infarcted myocardium, features a unique double-spacer structure that enhances electroactivity and enables wireless monitoring of electrocardiogram signals. The TRI-TENG patch uses a polydopamine (PDA)-modified reduced graphene oxide (rGO) membrane as a therapeutic electrode, converting biomechanical energy into electrical energy and monitoring cardiac activity. In vitro and in vivo tests demonstrate the patch's effectiveness in improving cardiac function, reducing fibrosis, and enhancing electrical conduction in rat and minipig models of myocardial infarction. The TRI-TENG patch shows superior performance compared to traditional conductive cardiac patches, making it a promising tool for cardiac repair and remote monitoring.