This review compares entrepreneurial ecosystems in the United States and Europe, highlighting their key characteristics, strengths, and challenges. The U.S. ecosystem is marked by world-class universities, a robust venture capital landscape, a culture that embraces risk and innovation, and supportive government policies. Silicon Valley and Boston exemplify this dynamic environment, fostering innovation and startup growth. In contrast, European ecosystems vary by region, influenced by cultural, regulatory, and historical factors. Berlin and London showcase distinct strengths, with Berlin's startup scene and London's fintech innovation. Both regions face common challenges, including access to capital, cultural attitudes toward risk, and regulatory constraints. The review identifies transferable best practices, such as fostering collaborative networks, ensuring access to capital, and creating supportive regulatory environments. Lessons from both regions emphasize the importance of innovation, impact entrepreneurship, and sustainability. Cross-cultural collaboration and global interconnectedness are critical for addressing shared challenges and fostering resilience. The future of entrepreneurial ecosystems is expected to be shaped by trends in technology, sustainability, and hybrid work models. Continued research and collaboration between stakeholders are essential for developing resilient, globally competitive ecosystems that drive innovation and economic growth. The review underscores the need for policies that support entrepreneurship, promote diversity, and encourage cross-border collaboration to create vibrant, inclusive entrepreneurial environments.This review compares entrepreneurial ecosystems in the United States and Europe, highlighting their key characteristics, strengths, and challenges. The U.S. ecosystem is marked by world-class universities, a robust venture capital landscape, a culture that embraces risk and innovation, and supportive government policies. Silicon Valley and Boston exemplify this dynamic environment, fostering innovation and startup growth. In contrast, European ecosystems vary by region, influenced by cultural, regulatory, and historical factors. Berlin and London showcase distinct strengths, with Berlin's startup scene and London's fintech innovation. Both regions face common challenges, including access to capital, cultural attitudes toward risk, and regulatory constraints. The review identifies transferable best practices, such as fostering collaborative networks, ensuring access to capital, and creating supportive regulatory environments. Lessons from both regions emphasize the importance of innovation, impact entrepreneurship, and sustainability. Cross-cultural collaboration and global interconnectedness are critical for addressing shared challenges and fostering resilience. The future of entrepreneurial ecosystems is expected to be shaped by trends in technology, sustainability, and hybrid work models. Continued research and collaboration between stakeholders are essential for developing resilient, globally competitive ecosystems that drive innovation and economic growth. The review underscores the need for policies that support entrepreneurship, promote diversity, and encourage cross-border collaboration to create vibrant, inclusive entrepreneurial environments.