The ESHRE (European Society of Human Reproduction and Embryology) guideline on the management of women with premature ovarian insufficiency (POI) provides best practice advice for the care of women with POI, both primary and secondary. The guideline covers diagnosis, assessment, and treatment, including hormonal therapy, and addresses the health consequences of POI such as fertility, bone health, cardiovascular issues, psychosexual function, psychological function, and neurological function. The guideline is based on a systematic literature review and expert consensus, with 95 recommendations and 4 statements. Key recommendations include the use of 17β-estradiol for puberty induction, hormone replacement therapy (HRT) for symptom management, and the importance of monitoring and follow-up. The guideline acknowledges limitations due to insufficient high-quality evidence and suggests areas for future research. Despite these limitations, the guideline aims to guide healthcare professionals in providing optimal care for women with POI.The ESHRE (European Society of Human Reproduction and Embryology) guideline on the management of women with premature ovarian insufficiency (POI) provides best practice advice for the care of women with POI, both primary and secondary. The guideline covers diagnosis, assessment, and treatment, including hormonal therapy, and addresses the health consequences of POI such as fertility, bone health, cardiovascular issues, psychosexual function, psychological function, and neurological function. The guideline is based on a systematic literature review and expert consensus, with 95 recommendations and 4 statements. Key recommendations include the use of 17β-estradiol for puberty induction, hormone replacement therapy (HRT) for symptom management, and the importance of monitoring and follow-up. The guideline acknowledges limitations due to insufficient high-quality evidence and suggests areas for future research. Despite these limitations, the guideline aims to guide healthcare professionals in providing optimal care for women with POI.