Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and a leading cause of cancer-related deaths worldwide. The diagnosis of HCC can be noninvasively confirmed in high-risk patients using contrast-enhanced CT or MRI, based on specific imaging criteria. These guidelines are provided by the European Association for the Study of the Liver (EASL), the American Association for the Study of Liver Diseases (AASLD), the Korean Liver Cancer Association-National Cancer Center (KLCA-NCC), and the Asian-Pacific Association for the Study of the Liver (APASL). Key imaging features include size, non-rim arterial phase hyperenhancement, non-peripheral washout, enhancing capsule, and growth. These criteria should be combined for a definitive diagnosis. The article provides concise practice recommendations for general radiologists, emphasizing the essential imaging criteria and high-risk population criteria. Contrast-enhanced CT and MRI are the primary imaging modalities, with MRI being preferred due to its higher sensitivity and resolution. Contrast-enhanced ultrasound can be used in experienced centers as a problem-solving technique. The article also discusses the importance of adequate imaging technique and the limitations of certain features, such as hepatobiliary phase hypointensity, which can increase sensitivity but reduce specificity.Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and a leading cause of cancer-related deaths worldwide. The diagnosis of HCC can be noninvasively confirmed in high-risk patients using contrast-enhanced CT or MRI, based on specific imaging criteria. These guidelines are provided by the European Association for the Study of the Liver (EASL), the American Association for the Study of Liver Diseases (AASLD), the Korean Liver Cancer Association-National Cancer Center (KLCA-NCC), and the Asian-Pacific Association for the Study of the Liver (APASL). Key imaging features include size, non-rim arterial phase hyperenhancement, non-peripheral washout, enhancing capsule, and growth. These criteria should be combined for a definitive diagnosis. The article provides concise practice recommendations for general radiologists, emphasizing the essential imaging criteria and high-risk population criteria. Contrast-enhanced CT and MRI are the primary imaging modalities, with MRI being preferred due to its higher sensitivity and resolution. Contrast-enhanced ultrasound can be used in experienced centers as a problem-solving technique. The article also discusses the importance of adequate imaging technique and the limitations of certain features, such as hepatobiliary phase hypointensity, which can increase sensitivity but reduce specificity.