The European Society of Urogenital Radiology (ESUR) has developed clinical guidelines for multi-parametric MRI (mp-MRI) of the prostate, aiming to promote high-quality MRI acquisition and evaluation with appropriate indications for prostate cancer across Europe. The guidelines cover the optimal technique and three protocols for "detection," "staging," and "node and bone." Key points include the use of endorectal coils vs. pelvic phased array coils and 1.5 vs. 3 T magnets. The guidelines also present clinical indications and a PI-RADS classification for structured reporting. The report emphasizes the importance of mp-MRI in managing low-risk patients, staging intermediate-risk patients, and assessing nodal size and bone marrow metastases in high-risk patients. Additionally, it discusses the role of mp-MRI in detecting tumor aggression and guiding further biopsy for accurate grading. The guidelines aim to improve the accuracy and efficiency of prostate cancer diagnosis and treatment.The European Society of Urogenital Radiology (ESUR) has developed clinical guidelines for multi-parametric MRI (mp-MRI) of the prostate, aiming to promote high-quality MRI acquisition and evaluation with appropriate indications for prostate cancer across Europe. The guidelines cover the optimal technique and three protocols for "detection," "staging," and "node and bone." Key points include the use of endorectal coils vs. pelvic phased array coils and 1.5 vs. 3 T magnets. The guidelines also present clinical indications and a PI-RADS classification for structured reporting. The report emphasizes the importance of mp-MRI in managing low-risk patients, staging intermediate-risk patients, and assessing nodal size and bone marrow metastases in high-risk patients. Additionally, it discusses the role of mp-MRI in detecting tumor aggression and guiding further biopsy for accurate grading. The guidelines aim to improve the accuracy and efficiency of prostate cancer diagnosis and treatment.