This article discusses the role of early life programming in neurodevelopmental disorders, emphasizing the interaction between genes and environment. It highlights how early life experiences, such as maternal stress, diet, and infections, can influence the development of conditions like schizophrenia, autism, and depression. The study reviews the mechanisms by which these experiences affect brain development, including epigenetic changes such as DNA methylation, histone modifications, and non-coding RNAs. It also explores the impact of maternal nutrition on offspring health, showing that prenatal undernutrition can increase the risk of schizophrenia. The article discusses the importance of understanding these mechanisms to develop effective interventions for neurodevelopmental disorders. It also addresses the role of sex in disease susceptibility, noting that some disorders are more prevalent in males or females. The study concludes that further research is needed to better understand the complex interplay between early life experiences and neurodevelopmental outcomes.This article discusses the role of early life programming in neurodevelopmental disorders, emphasizing the interaction between genes and environment. It highlights how early life experiences, such as maternal stress, diet, and infections, can influence the development of conditions like schizophrenia, autism, and depression. The study reviews the mechanisms by which these experiences affect brain development, including epigenetic changes such as DNA methylation, histone modifications, and non-coding RNAs. It also explores the impact of maternal nutrition on offspring health, showing that prenatal undernutrition can increase the risk of schizophrenia. The article discusses the importance of understanding these mechanisms to develop effective interventions for neurodevelopmental disorders. It also addresses the role of sex in disease susceptibility, noting that some disorders are more prevalent in males or females. The study concludes that further research is needed to better understand the complex interplay between early life experiences and neurodevelopmental outcomes.