Early skin-to-skin contact (SSC) between mothers and healthy newborns is a critical intervention that may improve breastfeeding outcomes, infant physiological stability, and maternal-infant bonding. A systematic review of 34 randomized controlled trials involving 2177 mother-infant dyads found that early SSC significantly increased breastfeeding rates and duration, with a risk ratio of 1.27 (95% CI 1.06 to 1.53) for breastfeeding at one to four months postbirth. SSC also improved cardio-respiratory stability in late preterm infants and increased blood glucose levels in the first 75-90 minutes after birth. However, the results did not reach statistical significance for all outcomes, and there was high heterogeneity among studies. The overall methodological quality of the trials was mixed, and there were variations in intervention implementation and outcomes. Early SSC was associated with reduced infant crying, improved maternal bonding, and no apparent short- or long-term negative effects. The review highlights the importance of consistent outcome measures for future research and emphasizes the need for further investigation to confirm the benefits of early SSC. The findings suggest that early SSC is a beneficial intervention for breastfeeding and infant physiological stability, and that future studies should use standardized outcome measures to facilitate meta-analysis. The review also notes that early SSC may reduce maternal stress and improve maternal confidence, which are important factors in breastfeeding success. Overall, the evidence supports the use of early SSC as a beneficial intervention for healthy newborns and their mothers.Early skin-to-skin contact (SSC) between mothers and healthy newborns is a critical intervention that may improve breastfeeding outcomes, infant physiological stability, and maternal-infant bonding. A systematic review of 34 randomized controlled trials involving 2177 mother-infant dyads found that early SSC significantly increased breastfeeding rates and duration, with a risk ratio of 1.27 (95% CI 1.06 to 1.53) for breastfeeding at one to four months postbirth. SSC also improved cardio-respiratory stability in late preterm infants and increased blood glucose levels in the first 75-90 minutes after birth. However, the results did not reach statistical significance for all outcomes, and there was high heterogeneity among studies. The overall methodological quality of the trials was mixed, and there were variations in intervention implementation and outcomes. Early SSC was associated with reduced infant crying, improved maternal bonding, and no apparent short- or long-term negative effects. The review highlights the importance of consistent outcome measures for future research and emphasizes the need for further investigation to confirm the benefits of early SSC. The findings suggest that early SSC is a beneficial intervention for breastfeeding and infant physiological stability, and that future studies should use standardized outcome measures to facilitate meta-analysis. The review also notes that early SSC may reduce maternal stress and improve maternal confidence, which are important factors in breastfeeding success. Overall, the evidence supports the use of early SSC as a beneficial intervention for healthy newborns and their mothers.