The article "Eco-friendly bio-nanocomposites: pioneering sustainable biomedical advancements in engineering" by J. Nandhini, E. Karthikeyan, and S. Rajeshkumar explores the emerging field of bio-nanocomposites, which are advanced materials combining biopolymers with nanoscale fillers. These materials enhance mechanical strength, thermal stability, and biocompatibility, making them ideal for applications such as tissue engineering, drug delivery, and diagnostic imaging. The biodegradability and non-toxic nature of these materials minimize environmental impact, making them a game-changer in sustainable biomedical advancements. The article discusses various preparation techniques, including solution intercalation, melt interaction, in situ intercalative polymerization, template synthesis, emulsification solvent diffusion, double emulsion solvent evaporation, electrospinning, ultrasonication, and using mammalian scaffolds. It also highlights the diverse applications of bio-nanocomposites, such as antimicrobial agents, drug carriers, tissue regeneration, wound care, dentistry, bioimaging, and bone filler. The authors acknowledge potential issues and the need for further research to ensure compatibility with biological systems, emphasizing the potential for personalized medicine and targeted therapies. The review concludes by discussing the biocompatibility and future prospects of bio-nanocomposites in healthcare.The article "Eco-friendly bio-nanocomposites: pioneering sustainable biomedical advancements in engineering" by J. Nandhini, E. Karthikeyan, and S. Rajeshkumar explores the emerging field of bio-nanocomposites, which are advanced materials combining biopolymers with nanoscale fillers. These materials enhance mechanical strength, thermal stability, and biocompatibility, making them ideal for applications such as tissue engineering, drug delivery, and diagnostic imaging. The biodegradability and non-toxic nature of these materials minimize environmental impact, making them a game-changer in sustainable biomedical advancements. The article discusses various preparation techniques, including solution intercalation, melt interaction, in situ intercalative polymerization, template synthesis, emulsification solvent diffusion, double emulsion solvent evaporation, electrospinning, ultrasonication, and using mammalian scaffolds. It also highlights the diverse applications of bio-nanocomposites, such as antimicrobial agents, drug carriers, tissue regeneration, wound care, dentistry, bioimaging, and bone filler. The authors acknowledge potential issues and the need for further research to ensure compatibility with biological systems, emphasizing the potential for personalized medicine and targeted therapies. The review concludes by discussing the biocompatibility and future prospects of bio-nanocomposites in healthcare.