This study updates and quantifies the economic burden of diagnosed diabetes in the U.S. in 2017, focusing on health resource use and lost productivity. The total estimated cost is $327 billion, with $237 billion in direct medical costs and $90 billion in reduced productivity. People with diagnosed diabetes incur an average of $16,750 per year in medical expenditures, of which $9,600 is attributed to diabetes. Indirect costs include increased absenteeism, reduced productivity, and premature mortality. The economic burden has increased by 26% from 2012 to 2017, primarily due to the growing prevalence of diabetes and higher costs per person. The study highlights the substantial financial and societal impact of diabetes, emphasizing the need for strategies to reduce its prevalence and burden.This study updates and quantifies the economic burden of diagnosed diabetes in the U.S. in 2017, focusing on health resource use and lost productivity. The total estimated cost is $327 billion, with $237 billion in direct medical costs and $90 billion in reduced productivity. People with diagnosed diabetes incur an average of $16,750 per year in medical expenditures, of which $9,600 is attributed to diabetes. Indirect costs include increased absenteeism, reduced productivity, and premature mortality. The economic burden has increased by 26% from 2012 to 2017, primarily due to the growing prevalence of diabetes and higher costs per person. The study highlights the substantial financial and societal impact of diabetes, emphasizing the need for strategies to reduce its prevalence and burden.