Extracellular vesicles (EVs) derived from edible plants offer a promising alternative for delivering mRNA vaccines, particularly for oral administration. These EVs, obtained from plant sources like orange juice, can protect mRNA from enzymatic degradation and remain stable at room temperature for up to a year. They have been shown to induce immune responses in animals, including the production of blocking antibodies and activation of Th1 lymphocytes. Plant-derived EVs are non-toxic, non-immunogenic, and can be easily extracted in large quantities, making them suitable for vaccine development. Studies have demonstrated that EVs loaded with SARS-CoV-2 mRNA can trigger both humoral and cellular immune responses, suggesting their potential for developing effective oral vaccines. Compared to synthetic nanoparticles, plant-derived EVs have advantages such as better stability, lower toxicity, and the ability to cross biological barriers. The use of EVs for vaccine delivery is supported by their ability to carry antigens and stimulate immune responses. Research indicates that plant-derived EVs could be a versatile and effective platform for mucosal vaccine delivery, offering a safe and efficient method for inducing immune responses. The study highlights the potential of edible plant-derived EVs as a novel and promising approach for developing oral mRNA vaccines.Extracellular vesicles (EVs) derived from edible plants offer a promising alternative for delivering mRNA vaccines, particularly for oral administration. These EVs, obtained from plant sources like orange juice, can protect mRNA from enzymatic degradation and remain stable at room temperature for up to a year. They have been shown to induce immune responses in animals, including the production of blocking antibodies and activation of Th1 lymphocytes. Plant-derived EVs are non-toxic, non-immunogenic, and can be easily extracted in large quantities, making them suitable for vaccine development. Studies have demonstrated that EVs loaded with SARS-CoV-2 mRNA can trigger both humoral and cellular immune responses, suggesting their potential for developing effective oral vaccines. Compared to synthetic nanoparticles, plant-derived EVs have advantages such as better stability, lower toxicity, and the ability to cross biological barriers. The use of EVs for vaccine delivery is supported by their ability to carry antigens and stimulate immune responses. Research indicates that plant-derived EVs could be a versatile and effective platform for mucosal vaccine delivery, offering a safe and efficient method for inducing immune responses. The study highlights the potential of edible plant-derived EVs as a novel and promising approach for developing oral mRNA vaccines.