This review, authored by a team of researchers from various institutions in Taiwan, the United States, and Mexico, highlights the advancements in electrochemical sensors for improving food safety, quality, and traceability. Electrochemical sensors have become crucial tools in ensuring the safety of the global food supply chain, which is essential for public health, economic stability, and environmental sustainability. The review covers recent developments in sensor technology, including their operating principles, types, cutting-edge materials, and methods enhancing their effectiveness. These sensors are adept at detecting a broad range of foodborne pathogens, chemical contaminants, and adulterants while monitoring food freshness and quality. Innovations include the use of nanomaterials and conductive polymers, as well as the development of miniaturized, portable devices for on-site and real-time analysis. The review also addresses challenges such as sensitivity, selectivity, and matrix effects, and discusses regulatory and standardization issues relevant to adopting these technologies in food safety protocols. The authors emphasize the indispensable role of electrochemical sensors in boosting food safety and security and the need for ongoing innovation and cross-disciplinary cooperation to advance this area.This review, authored by a team of researchers from various institutions in Taiwan, the United States, and Mexico, highlights the advancements in electrochemical sensors for improving food safety, quality, and traceability. Electrochemical sensors have become crucial tools in ensuring the safety of the global food supply chain, which is essential for public health, economic stability, and environmental sustainability. The review covers recent developments in sensor technology, including their operating principles, types, cutting-edge materials, and methods enhancing their effectiveness. These sensors are adept at detecting a broad range of foodborne pathogens, chemical contaminants, and adulterants while monitoring food freshness and quality. Innovations include the use of nanomaterials and conductive polymers, as well as the development of miniaturized, portable devices for on-site and real-time analysis. The review also addresses challenges such as sensitivity, selectivity, and matrix effects, and discusses regulatory and standardization issues relevant to adopting these technologies in food safety protocols. The authors emphasize the indispensable role of electrochemical sensors in boosting food safety and security and the need for ongoing innovation and cross-disciplinary cooperation to advance this area.