This review evaluates the effects of educational outreach visits (EOVs) on professional practice and healthcare outcomes. EOVs are face-to-face visits by trained individuals to healthcare professionals in their settings, aimed at improving their performance. The review includes 69 studies involving over 15,000 healthcare professionals. The median adjusted risk difference (RD) in compliance with desired practice was 5.6% (interquartile range 3.0% to 9.0%). EOVs showed consistent small improvements in prescribing behavior (median RD 4.8%, interquartile range 3.0% to 6.5%) but varied effects for other professional practices (median RD 6.0%, interquartile range 3.6% to 16.0%). Meta-regression analysis did not identify significant factors explaining the variation in effects. EOVs appeared slightly more effective than audit and feedback interventions. However, only six studies compared different types of visits, with mixed results. Overall, EOVs can improve practice, particularly in prescribing, but the effects vary and are often small.This review evaluates the effects of educational outreach visits (EOVs) on professional practice and healthcare outcomes. EOVs are face-to-face visits by trained individuals to healthcare professionals in their settings, aimed at improving their performance. The review includes 69 studies involving over 15,000 healthcare professionals. The median adjusted risk difference (RD) in compliance with desired practice was 5.6% (interquartile range 3.0% to 9.0%). EOVs showed consistent small improvements in prescribing behavior (median RD 4.8%, interquartile range 3.0% to 6.5%) but varied effects for other professional practices (median RD 6.0%, interquartile range 3.6% to 16.0%). Meta-regression analysis did not identify significant factors explaining the variation in effects. EOVs appeared slightly more effective than audit and feedback interventions. However, only six studies compared different types of visits, with mixed results. Overall, EOVs can improve practice, particularly in prescribing, but the effects vary and are often small.