This systematic review examines the effects of robot-assisted therapy on motor and functional recovery in patients with stroke. The review includes ten randomized clinical trials involving 218 patients, with methodological quality ranging from 4 to 8 on a 10-point scale. The meta-analysis found no significant overall effect of robot-assisted therapy on upper limb motor recovery, but a sensitivity analysis showed a significant improvement in motor recovery for upper arm robotics. No significant improvement was observed in activities of daily living (ADL). The review suggests that future research should focus on kinematic analysis to differentiate between genuine upper limb motor recovery and functional recovery due to compensation strategies. Additionally, the cost-effectiveness of robot-assisted therapy needs to be investigated, especially given the increasing pressure to reduce healthcare costs.This systematic review examines the effects of robot-assisted therapy on motor and functional recovery in patients with stroke. The review includes ten randomized clinical trials involving 218 patients, with methodological quality ranging from 4 to 8 on a 10-point scale. The meta-analysis found no significant overall effect of robot-assisted therapy on upper limb motor recovery, but a sensitivity analysis showed a significant improvement in motor recovery for upper arm robotics. No significant improvement was observed in activities of daily living (ADL). The review suggests that future research should focus on kinematic analysis to differentiate between genuine upper limb motor recovery and functional recovery due to compensation strategies. Additionally, the cost-effectiveness of robot-assisted therapy needs to be investigated, especially given the increasing pressure to reduce healthcare costs.