This review discusses the complex interactions between plants and abiotic stresses, emphasizing the role of systems biology in understanding these interactions. Systems biology approaches, including transcriptomics, metabolomics, and proteomics, have facilitated the identification of regulatory hubs and pathways in plant responses to stress. The review highlights recent advances in gene discovery and functional genomics, which have provided a holistic view of cellular processes. It also addresses the challenges in understanding plant responses to stress, such as the complexity of cellular organization and the dynamic nature of stress responses. The integration of omics data has revealed new insights into the molecular networks involved in stress responses, particularly the roles of hormones like abscisic acid (ABA) and ethylene. Time-series analyses have identified multiple phases in stress responses, with early downregulation of energy metabolism and protein synthesis. The review concludes by discussing the potential for using systems biology to develop stress-tolerant crops and the need for further research to fully understand plant responses to abiotic stresses.This review discusses the complex interactions between plants and abiotic stresses, emphasizing the role of systems biology in understanding these interactions. Systems biology approaches, including transcriptomics, metabolomics, and proteomics, have facilitated the identification of regulatory hubs and pathways in plant responses to stress. The review highlights recent advances in gene discovery and functional genomics, which have provided a holistic view of cellular processes. It also addresses the challenges in understanding plant responses to stress, such as the complexity of cellular organization and the dynamic nature of stress responses. The integration of omics data has revealed new insights into the molecular networks involved in stress responses, particularly the roles of hormones like abscisic acid (ABA) and ethylene. Time-series analyses have identified multiple phases in stress responses, with early downregulation of energy metabolism and protein synthesis. The review concludes by discussing the potential for using systems biology to develop stress-tolerant crops and the need for further research to fully understand plant responses to abiotic stresses.