The article discusses the impact of extracellular matrix (ECM) viscoelasticity on cellular behavior, highlighting that tissues and ECMs are not purely elastic but exhibit complex mechanical behaviors, including viscoelasticity, plasticity, and nonlinear elasticity. These properties influence fundamental cell processes such as spreading, growth, proliferation, migration, differentiation, and organoid formation. While earlier studies focused on substrate stiffness, recent research has shown that viscoelasticity plays a critical role in cell-matrix interactions and mechanosensitive pathways. The study reviews the complex mechanical behaviors of tissues and ECMs, discusses recent findings on ECM viscoelasticity, and explores the potential of viscoelastic biomaterials in regenerative medicine. It emphasizes that the mechanical properties of tissues, including viscoelasticity, are crucial for development, homeostasis, regenerative processes, and disease progression. The article also highlights the importance of considering viscoelasticity in biomaterial design for regenerative medicine, as it can influence cell behavior, proliferation, and tissue regeneration. The study concludes that viscoelasticity is a key factor in cell-matrix interactions and that future research should focus on understanding its role in cellular and tissue responses to biomaterials.The article discusses the impact of extracellular matrix (ECM) viscoelasticity on cellular behavior, highlighting that tissues and ECMs are not purely elastic but exhibit complex mechanical behaviors, including viscoelasticity, plasticity, and nonlinear elasticity. These properties influence fundamental cell processes such as spreading, growth, proliferation, migration, differentiation, and organoid formation. While earlier studies focused on substrate stiffness, recent research has shown that viscoelasticity plays a critical role in cell-matrix interactions and mechanosensitive pathways. The study reviews the complex mechanical behaviors of tissues and ECMs, discusses recent findings on ECM viscoelasticity, and explores the potential of viscoelastic biomaterials in regenerative medicine. It emphasizes that the mechanical properties of tissues, including viscoelasticity, are crucial for development, homeostasis, regenerative processes, and disease progression. The article also highlights the importance of considering viscoelasticity in biomaterial design for regenerative medicine, as it can influence cell behavior, proliferation, and tissue regeneration. The study concludes that viscoelasticity is a key factor in cell-matrix interactions and that future research should focus on understanding its role in cellular and tissue responses to biomaterials.