Efficacy of Tocilizumab in Patients Hospitalized with Covid-19

Efficacy of Tocilizumab in Patients Hospitalized with Covid-19

December 10, 2020 | John H. Stone, Matthew J. Frigault, Naomi J. Serling-Boyd et al.
**Medicine and Health:** - **Tocilizumab Efficacy:** A randomized controlled trial found that tocilizumab, an IL-6 receptor blocker, had no significant effect on disease progression, independence from supplemental oxygen, or death in patients with COVID-19. - **Low Dose Radiotherapy:** A qualitative study explored clinicians' perspectives on using low dose radiotherapy (LDRT) to treat COVID-19 lung disease, identifying barriers to its implementation. - **ChAdOx1 nCoV-19 Vaccine:** An interim analysis of four randomized controlled trials showed that the ChAdOx1 nCoV-19 vaccine is safe and efficacious against symptomatic COVID-19. - **Oxygen Saturation in Older Adults:** A study found that wearing a 3-layer nonmedical face mask did not cause a decline in oxygen saturation in older adults. - **Fluvoxamine for COVID-19:** A randomized trial compared the effects of fluvoxamine, a selective serotonin reuptake inhibitor, with placebo on dyspnoea or pneumonia and oxygen desaturation in outpatients with mild COVID-19. - **Pulmonary Embolism in COVID-19 Patients:** A nested case-control study in France found a prevalence of pulmonary embolism (PE) of nearly 5% in COVID-19 patients, associated with more extensive lung damage and invasive ventilation. **Science and Engineering:** - **X-ray Image Classification:** A method using an enhanced cuckoo search optimization algorithm with fractional-order calculus and heavy-tailed distributions was proposed for classifying COVID-19 X-ray images. - **Epidemic Model:** An individual-based epidemic model with latent-infectious-recovery periods was developed and applied to compare COVID-19 in New York City and Wuhan, showing a 30% higher transmission rate in NYC. - **Lockdown Impact:** A study analyzed phase-wise variations in aerosol, radiation, and trace gases during the COVID-19 lockdown in a tropical rural environment, finding that air quality remained stable despite reduced pollutants. - **Air Contamination in Hospitals:** A review of current evidence on air contamination with SARS-CoV-2 in hospital settings identified high viral loads in toilets, staff areas, and public hallways. **Social Sciences, Humanities, and Public Policies:** - **Economic Sentiment:** A study using internet search data showed a significant shift in economic sentiment during the COVID pandemic, with increased concerns about unemployment and labor market slowdowns. - **Economic Stimulus:** A cross-country analysis proposed a multidimensional index to standardize governments' economic responses to the pandemic, identifying Chile, Switzerland, Croatia, Sweden, and the Netherlands as strong responders. - **Healthcare Chaplaincy:** A study suggested that evolutionary psychology and social neuroscience can inform the development of effective healthcare chaplaincy practices in the context of**Medicine and Health:** - **Tocilizumab Efficacy:** A randomized controlled trial found that tocilizumab, an IL-6 receptor blocker, had no significant effect on disease progression, independence from supplemental oxygen, or death in patients with COVID-19. - **Low Dose Radiotherapy:** A qualitative study explored clinicians' perspectives on using low dose radiotherapy (LDRT) to treat COVID-19 lung disease, identifying barriers to its implementation. - **ChAdOx1 nCoV-19 Vaccine:** An interim analysis of four randomized controlled trials showed that the ChAdOx1 nCoV-19 vaccine is safe and efficacious against symptomatic COVID-19. - **Oxygen Saturation in Older Adults:** A study found that wearing a 3-layer nonmedical face mask did not cause a decline in oxygen saturation in older adults. - **Fluvoxamine for COVID-19:** A randomized trial compared the effects of fluvoxamine, a selective serotonin reuptake inhibitor, with placebo on dyspnoea or pneumonia and oxygen desaturation in outpatients with mild COVID-19. - **Pulmonary Embolism in COVID-19 Patients:** A nested case-control study in France found a prevalence of pulmonary embolism (PE) of nearly 5% in COVID-19 patients, associated with more extensive lung damage and invasive ventilation. **Science and Engineering:** - **X-ray Image Classification:** A method using an enhanced cuckoo search optimization algorithm with fractional-order calculus and heavy-tailed distributions was proposed for classifying COVID-19 X-ray images. - **Epidemic Model:** An individual-based epidemic model with latent-infectious-recovery periods was developed and applied to compare COVID-19 in New York City and Wuhan, showing a 30% higher transmission rate in NYC. - **Lockdown Impact:** A study analyzed phase-wise variations in aerosol, radiation, and trace gases during the COVID-19 lockdown in a tropical rural environment, finding that air quality remained stable despite reduced pollutants. - **Air Contamination in Hospitals:** A review of current evidence on air contamination with SARS-CoV-2 in hospital settings identified high viral loads in toilets, staff areas, and public hallways. **Social Sciences, Humanities, and Public Policies:** - **Economic Sentiment:** A study using internet search data showed a significant shift in economic sentiment during the COVID pandemic, with increased concerns about unemployment and labor market slowdowns. - **Economic Stimulus:** A cross-country analysis proposed a multidimensional index to standardize governments' economic responses to the pandemic, identifying Chile, Switzerland, Croatia, Sweden, and the Netherlands as strong responders. - **Healthcare Chaplaincy:** A study suggested that evolutionary psychology and social neuroscience can inform the development of effective healthcare chaplaincy practices in the context of
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