The study investigates the oxygen evolution reaction (OER) using alpha-manganese dioxide (α-MnO₂) as a model to adjust proton coupling. The research reveals that pre-equilibrium proton-coupled redox transitions provide an adjustable energy profile for OER, which can be enhanced through an external electric field. Using α-MnO₂ single-nanowire devices, gate voltage induces a 4-fold increase in OER current density at 1.7 V versus reversible hydrogen electrode. Additionally, an external electric field-assisted flow cell for water splitting demonstrates a 34% increase in current density and a 44.7 mW/cm² increase in net output power. These findings highlight the importance of proton-incorporated redox transitions and provide a practical approach for high-efficiency electrocatalysis. The study also explores the structural and functional role of μ-oxo di-manganese structures and protons in the OER process, and demonstrates the effectiveness of an external electric field in enhancing deprotonation and proton coupling, leading to a significantly lower overpotential of 360 mV at 100 mA/cm².The study investigates the oxygen evolution reaction (OER) using alpha-manganese dioxide (α-MnO₂) as a model to adjust proton coupling. The research reveals that pre-equilibrium proton-coupled redox transitions provide an adjustable energy profile for OER, which can be enhanced through an external electric field. Using α-MnO₂ single-nanowire devices, gate voltage induces a 4-fold increase in OER current density at 1.7 V versus reversible hydrogen electrode. Additionally, an external electric field-assisted flow cell for water splitting demonstrates a 34% increase in current density and a 44.7 mW/cm² increase in net output power. These findings highlight the importance of proton-incorporated redox transitions and provide a practical approach for high-efficiency electrocatalysis. The study also explores the structural and functional role of μ-oxo di-manganese structures and protons in the OER process, and demonstrates the effectiveness of an external electric field in enhancing deprotonation and proton coupling, leading to a significantly lower overpotential of 360 mV at 100 mA/cm².