2024 | Akinrinade George Ayankojo, Jekaterina Reut, Vitali Syritski
This review discusses the recent advancements in the application of electrochemically synthesized molecularly imprinted polymers (MIPs) for the detection of disease biomarkers in healthcare diagnostics. MIPs, known for their selectivity, stability, simplicity, and low preparation costs, have become increasingly popular in the development of advanced sensing devices. Electrochemical synthesis is highlighted as a unique and effective method for MIP formation, allowing direct polymer deposition on transducers and easy tuning of film properties. The review covers various diseases, including cancer, cardiovascular problems, inflammatory disorders, neurological disorders, and infectious diseases, detailing the specific biomarkers detected and the performance of MIP-based sensors. Key techniques such as surface imprinting, epitope imprinting, and the integration of nanomaterials are discussed, along with the advantages and challenges of each approach. The review also emphasizes the potential of MIP-based sensors for point-of-care testing (POCT) and wearable devices, providing a comprehensive overview of the current state and future prospects of this field.This review discusses the recent advancements in the application of electrochemically synthesized molecularly imprinted polymers (MIPs) for the detection of disease biomarkers in healthcare diagnostics. MIPs, known for their selectivity, stability, simplicity, and low preparation costs, have become increasingly popular in the development of advanced sensing devices. Electrochemical synthesis is highlighted as a unique and effective method for MIP formation, allowing direct polymer deposition on transducers and easy tuning of film properties. The review covers various diseases, including cancer, cardiovascular problems, inflammatory disorders, neurological disorders, and infectious diseases, detailing the specific biomarkers detected and the performance of MIP-based sensors. Key techniques such as surface imprinting, epitope imprinting, and the integration of nanomaterials are discussed, along with the advantages and challenges of each approach. The review also emphasizes the potential of MIP-based sensors for point-of-care testing (POCT) and wearable devices, providing a comprehensive overview of the current state and future prospects of this field.