Electrochemically synthesized molecularly imprinted polymers (MIPs) are increasingly used as artificial receptors in sensing devices due to their selectivity, stability, simplicity, and low cost. Electrochemical synthesis allows direct polymer formation on the transducer and easy tuning of film properties, making it a promising method for commercial MIP-based sensors. This review highlights recent advances in the application of electrosynthesized MIP sensors for clinical analysis of disease biomarkers, focusing on cancer, cardiovascular diseases, inflammatory disorders, neurological disorders, and infectious diseases. For cancer detection, MIP sensors have been developed for biomarkers such as CEA, CA15-3, CA125, Her-2, NSE, and 5-HIAA. These sensors offer high sensitivity and selectivity, with some achieving low detection limits and good performance in complex biological samples. In cardiovascular disease, MIP sensors have been used for detecting cardiac troponin (cTn), troponin-T (TnT), and myoglobin (Mb), with some sensors showing high sensitivity and selectivity. For inflammatory disorders, MIP sensors have been developed for detecting interleukin-6 (IL-6) and 3-nitrotyrosine (3-NT), with some sensors demonstrating excellent performance in detecting these biomarkers. In neurological disorders, MIP sensors have been used for detecting neurotransmitters such as dopamine (DA), serotonin (SER), and epinephrine (adrenaline), as well as biomarkers like α-synuclein and amyloid-β (Aβ-42). For infectious diseases, MIP sensors have been developed for detecting biomarkers related to viruses such as influenza, Zika, and COVID-19. The review also discusses the advantages of electrosynthesis, including precise control of polymer deposition, the ability to create thin films, and the use of green synthesis methods. It highlights the importance of functional monomers and the role of computational modeling in optimizing MIP design. The review concludes that electrosynthesized MIP sensors offer a promising approach for the development of commercial diagnostic devices for rapid determination of disease biomarkers.Electrochemically synthesized molecularly imprinted polymers (MIPs) are increasingly used as artificial receptors in sensing devices due to their selectivity, stability, simplicity, and low cost. Electrochemical synthesis allows direct polymer formation on the transducer and easy tuning of film properties, making it a promising method for commercial MIP-based sensors. This review highlights recent advances in the application of electrosynthesized MIP sensors for clinical analysis of disease biomarkers, focusing on cancer, cardiovascular diseases, inflammatory disorders, neurological disorders, and infectious diseases. For cancer detection, MIP sensors have been developed for biomarkers such as CEA, CA15-3, CA125, Her-2, NSE, and 5-HIAA. These sensors offer high sensitivity and selectivity, with some achieving low detection limits and good performance in complex biological samples. In cardiovascular disease, MIP sensors have been used for detecting cardiac troponin (cTn), troponin-T (TnT), and myoglobin (Mb), with some sensors showing high sensitivity and selectivity. For inflammatory disorders, MIP sensors have been developed for detecting interleukin-6 (IL-6) and 3-nitrotyrosine (3-NT), with some sensors demonstrating excellent performance in detecting these biomarkers. In neurological disorders, MIP sensors have been used for detecting neurotransmitters such as dopamine (DA), serotonin (SER), and epinephrine (adrenaline), as well as biomarkers like α-synuclein and amyloid-β (Aβ-42). For infectious diseases, MIP sensors have been developed for detecting biomarkers related to viruses such as influenza, Zika, and COVID-19. The review also discusses the advantages of electrosynthesis, including precise control of polymer deposition, the ability to create thin films, and the use of green synthesis methods. It highlights the importance of functional monomers and the role of computational modeling in optimizing MIP design. The review concludes that electrosynthesized MIP sensors offer a promising approach for the development of commercial diagnostic devices for rapid determination of disease biomarkers.