This review discusses the development and application of electrospun antimicrobial drug delivery systems and hydrogels for wound dressings. Wounds and chronic wounds can be caused by bacterial infections, leading to discomfort in patients. Traditional materials are insufficient for complex wounds and do not promote healing. Electrospun wound dressings and hydrogels with antibacterial compounds can meet these requirements. The review covers recent materials used in wound dressings, their formation, application, and functionalization. It focuses on electrospun materials and hydrogels, highlighting the potential of thermoresponsive hydrogels as dynamic and antibacterial wound dressings. These hydrogels contain adaptable polymers that offer targeted drug delivery and show promise in managing various wound types while addressing bacterial infections. The article aims to serve as a compendium of knowledge for researchers, medical practitioners, and biomaterials engineers, providing up-to-date information on the state of the art, possibilities of innovative solutions, and potential challenges in the area of materials used in dressings. The review also discusses the development of various types of wound dressings, including traditional, interactive, and bioactive dressings. Electrospinning is an advanced technique for producing nanofibers with a diameter from several nanometers to several micrometers. Electrospun nanofibers have a high surface-to-volume ratio, which is advantageous in wound healing applications. They can promote the formation of new blood vessels and support the healing process. The review also discusses the use of antibacterial nanofibers for wound dressings, including the incorporation of silver nanoparticles, chitosan, and other antibacterial agents. The review highlights the potential of hydrogels with nanofibers and thermoresponsive hydrogels as wound dressings, emphasizing their ability to provide antibacterial and anti-inflammatory properties. The review concludes with the potential of these materials in addressing major issues associated with skin regeneration, such as scar formation, poor tissue integration, and bacterial infection.This review discusses the development and application of electrospun antimicrobial drug delivery systems and hydrogels for wound dressings. Wounds and chronic wounds can be caused by bacterial infections, leading to discomfort in patients. Traditional materials are insufficient for complex wounds and do not promote healing. Electrospun wound dressings and hydrogels with antibacterial compounds can meet these requirements. The review covers recent materials used in wound dressings, their formation, application, and functionalization. It focuses on electrospun materials and hydrogels, highlighting the potential of thermoresponsive hydrogels as dynamic and antibacterial wound dressings. These hydrogels contain adaptable polymers that offer targeted drug delivery and show promise in managing various wound types while addressing bacterial infections. The article aims to serve as a compendium of knowledge for researchers, medical practitioners, and biomaterials engineers, providing up-to-date information on the state of the art, possibilities of innovative solutions, and potential challenges in the area of materials used in dressings. The review also discusses the development of various types of wound dressings, including traditional, interactive, and bioactive dressings. Electrospinning is an advanced technique for producing nanofibers with a diameter from several nanometers to several micrometers. Electrospun nanofibers have a high surface-to-volume ratio, which is advantageous in wound healing applications. They can promote the formation of new blood vessels and support the healing process. The review also discusses the use of antibacterial nanofibers for wound dressings, including the incorporation of silver nanoparticles, chitosan, and other antibacterial agents. The review highlights the potential of hydrogels with nanofibers and thermoresponsive hydrogels as wound dressings, emphasizing their ability to provide antibacterial and anti-inflammatory properties. The review concludes with the potential of these materials in addressing major issues associated with skin regeneration, such as scar formation, poor tissue integration, and bacterial infection.