This study investigates the development of electrospun nanofibers as orthopedic hemostatic dressings, incorporating multiple functional ingredients such as fenoprofen, tranexamic acid (TA), and hydroxyapatite (HAP). The modified coaxial electrospinning technique was used to create core–shell nanofibers with different shell fluids, including pure solvent, nanosuspension of HAP and TA, and a dilute polymeric solution containing HAP, TA, and polyvinylpyrrolidone (PVP). The nanofibers exhibited a linear morphology with diameters less than 1.0 μm and showed good hydrophilicity, with water contact angles below 40°. In vitro dissolution tests demonstrated sustained release of fenoprofen over 6 hours through Fickian diffusion. Hemostatic tests indicated rapid hemostasis within 60 seconds due to the rapid release of TA from the nanofiber surface. The electrospun fenoprofen/PCL@TA/HAP/PVP nanofibers (F4) showed the most favorable characteristics, including rapid release of TA and HAP and extended release of fenoprofen, making them promising candidates for orthopedic hemostatic dressings.This study investigates the development of electrospun nanofibers as orthopedic hemostatic dressings, incorporating multiple functional ingredients such as fenoprofen, tranexamic acid (TA), and hydroxyapatite (HAP). The modified coaxial electrospinning technique was used to create core–shell nanofibers with different shell fluids, including pure solvent, nanosuspension of HAP and TA, and a dilute polymeric solution containing HAP, TA, and polyvinylpyrrolidone (PVP). The nanofibers exhibited a linear morphology with diameters less than 1.0 μm and showed good hydrophilicity, with water contact angles below 40°. In vitro dissolution tests demonstrated sustained release of fenoprofen over 6 hours through Fickian diffusion. Hemostatic tests indicated rapid hemostasis within 60 seconds due to the rapid release of TA from the nanofiber surface. The electrospun fenoprofen/PCL@TA/HAP/PVP nanofibers (F4) showed the most favorable characteristics, including rapid release of TA and HAP and extended release of fenoprofen, making them promising candidates for orthopedic hemostatic dressings.