A novel orthopedic hemostasis dressing composed of electrospun fenoprofen/polycaprolactone (PCL) @ tranexamic acid (TA)/hydroxyapatite (HAP) nanofibers was developed. This dressing combines multiple functions, including hemostasis, analgesia, anti-inflammatory effects, and bone regeneration. The nanofibers were fabricated using a modified coaxial electrospinning process, where a PCL/fenoprofen solution served as the core, and a TA/HAP suspension as the shell. The resulting nanofibers exhibited a linear morphology with diameters less than 1.0 μm, and some had incomplete core-shell structures. Scanning and transmission electron microscopy confirmed the nanofiber structure, while XRD and FTIR analyses showed that TA and fenoprofen were present in an amorphous state due to good compatibility between the components. The nanofibers demonstrated excellent hydrophilicity, with water contact angles below 40°, and sustained release of fenoprofen over 6 hours via Fickian diffusion. In vitro hemostatic tests showed rapid TA release within 60 seconds, leading to effective hemostasis. The combination of TA, HAP, and fenoprofen in the nanofibers provided a synergistic effect for hemostasis and bone healing. The dressing showed promising potential for orthopedic applications due to its multifunctional properties and controlled drug release.A novel orthopedic hemostasis dressing composed of electrospun fenoprofen/polycaprolactone (PCL) @ tranexamic acid (TA)/hydroxyapatite (HAP) nanofibers was developed. This dressing combines multiple functions, including hemostasis, analgesia, anti-inflammatory effects, and bone regeneration. The nanofibers were fabricated using a modified coaxial electrospinning process, where a PCL/fenoprofen solution served as the core, and a TA/HAP suspension as the shell. The resulting nanofibers exhibited a linear morphology with diameters less than 1.0 μm, and some had incomplete core-shell structures. Scanning and transmission electron microscopy confirmed the nanofiber structure, while XRD and FTIR analyses showed that TA and fenoprofen were present in an amorphous state due to good compatibility between the components. The nanofibers demonstrated excellent hydrophilicity, with water contact angles below 40°, and sustained release of fenoprofen over 6 hours via Fickian diffusion. In vitro hemostatic tests showed rapid TA release within 60 seconds, leading to effective hemostasis. The combination of TA, HAP, and fenoprofen in the nanofibers provided a synergistic effect for hemostasis and bone healing. The dressing showed promising potential for orthopedic applications due to its multifunctional properties and controlled drug release.