The study "Elevated body temperature is associated with depressive symptoms: results from the TemPredict Study" investigates the relationship between body temperature and depression in a large sample of participants. The study used both self-reported body temperature data and wearable sensor-assessed distal body temperature data to examine the association between body temperature and depressive symptoms. Key findings include: 1. **Higher Body Temperature**: Participants with higher self-reported and wearable sensor-assessed body temperatures during the awake state had greater depression symptom severity. 2. **Smaller Differences in Body Temperature Between Sleep and Wake**: There was a tendency for smaller differences in body temperature between sleep and wake states to be associated with greater depression symptom severity, though this association was not statistically significant. 3. **Lower Diurnal Body Temperature Amplitude**: Lower diurnal body temperature amplitude, as measured by wearable sensors, was also associated with greater depression symptom severity, though this association was not statistically significant. The study replicated and expanded upon previous findings from smaller studies, suggesting that body temperature alterations may be relevant factors in the etiology of depression. These findings have implications for the development of novel treatments for major depressive disorder, particularly those targeting thermoregulatory systems. The study used a large international sample (over 20,000 participants) and collected data over a period of about 7 months, providing robust evidence for the association between body temperature and depression.The study "Elevated body temperature is associated with depressive symptoms: results from the TemPredict Study" investigates the relationship between body temperature and depression in a large sample of participants. The study used both self-reported body temperature data and wearable sensor-assessed distal body temperature data to examine the association between body temperature and depressive symptoms. Key findings include: 1. **Higher Body Temperature**: Participants with higher self-reported and wearable sensor-assessed body temperatures during the awake state had greater depression symptom severity. 2. **Smaller Differences in Body Temperature Between Sleep and Wake**: There was a tendency for smaller differences in body temperature between sleep and wake states to be associated with greater depression symptom severity, though this association was not statistically significant. 3. **Lower Diurnal Body Temperature Amplitude**: Lower diurnal body temperature amplitude, as measured by wearable sensors, was also associated with greater depression symptom severity, though this association was not statistically significant. The study replicated and expanded upon previous findings from smaller studies, suggesting that body temperature alterations may be relevant factors in the etiology of depression. These findings have implications for the development of novel treatments for major depressive disorder, particularly those targeting thermoregulatory systems. The study used a large international sample (over 20,000 participants) and collected data over a period of about 7 months, providing robust evidence for the association between body temperature and depression.