Elevated body temperature is associated with depressive symptoms, according to findings from the TemPredict Study. The study analyzed data from over 20,000 participants, including self-reported and wearable sensor-assessed body temperatures, and self-reported depressive symptoms. Results showed that higher body temperatures during waking hours were linked to greater depression symptom severity. Lower diurnal body temperature amplitude, though not statistically significant, also showed a trend toward association with more severe depressive symptoms. These findings suggest that body temperature alterations may be relevant to depression etiology and could inform new treatment approaches for major depressive disorder. Depression has become a global health crisis, with rising prevalence in many countries, particularly among youth and young adults. Current treatments, such as antidepressants, have limited efficacy, highlighting the need for new therapeutic strategies. The TemPredict Study aimed to explore the relationship between body temperature and depression by analyzing data from a large, international sample. The study used both self-reported and wearable sensor data to assess body temperature and depressive symptoms. The study found that higher self-reported and wearable sensor-assessed body temperatures during waking hours were associated with greater depression symptom severity. Lower diurnal body temperature amplitude was also associated with more severe depressive symptoms, though this association did not reach statistical significance. These findings, derived from a large sample, support previous research indicating that body temperature alterations may be relevant to depression. The study also found that higher body temperatures were associated with increased odds of having depression, with the strongest associations observed in severe depression cases. Logistic regression models confirmed these findings, showing that higher body temperatures were linked to higher depression symptom severity. Receiver operating characteristic (ROC) curve analyses further supported these findings, demonstrating that body temperature could be a useful biomarker for detecting depression. The study used both self-reported and wearable sensor data to assess body temperature and depressive symptoms. Results showed that individuals with more severe depressive symptoms had higher body temperatures during waking hours and lower diurnal temperature amplitudes. These findings suggest that body temperature may be a potential biological marker for depression, and that interventions targeting thermoregulatory systems could be beneficial for treating depression. The study had several limitations, including potential measurement errors and the inability to assess the temporal relationship between body temperature changes and depressive symptoms. However, the findings support the hypothesis that body temperature alterations may be relevant to depression and could inform new treatment approaches. The study highlights the need for further research to clarify the biological pathways through which body temperature is altered in individuals with depression.Elevated body temperature is associated with depressive symptoms, according to findings from the TemPredict Study. The study analyzed data from over 20,000 participants, including self-reported and wearable sensor-assessed body temperatures, and self-reported depressive symptoms. Results showed that higher body temperatures during waking hours were linked to greater depression symptom severity. Lower diurnal body temperature amplitude, though not statistically significant, also showed a trend toward association with more severe depressive symptoms. These findings suggest that body temperature alterations may be relevant to depression etiology and could inform new treatment approaches for major depressive disorder. Depression has become a global health crisis, with rising prevalence in many countries, particularly among youth and young adults. Current treatments, such as antidepressants, have limited efficacy, highlighting the need for new therapeutic strategies. The TemPredict Study aimed to explore the relationship between body temperature and depression by analyzing data from a large, international sample. The study used both self-reported and wearable sensor data to assess body temperature and depressive symptoms. The study found that higher self-reported and wearable sensor-assessed body temperatures during waking hours were associated with greater depression symptom severity. Lower diurnal body temperature amplitude was also associated with more severe depressive symptoms, though this association did not reach statistical significance. These findings, derived from a large sample, support previous research indicating that body temperature alterations may be relevant to depression. The study also found that higher body temperatures were associated with increased odds of having depression, with the strongest associations observed in severe depression cases. Logistic regression models confirmed these findings, showing that higher body temperatures were linked to higher depression symptom severity. Receiver operating characteristic (ROC) curve analyses further supported these findings, demonstrating that body temperature could be a useful biomarker for detecting depression. The study used both self-reported and wearable sensor data to assess body temperature and depressive symptoms. Results showed that individuals with more severe depressive symptoms had higher body temperatures during waking hours and lower diurnal temperature amplitudes. These findings suggest that body temperature may be a potential biological marker for depression, and that interventions targeting thermoregulatory systems could be beneficial for treating depression. The study had several limitations, including potential measurement errors and the inability to assess the temporal relationship between body temperature changes and depressive symptoms. However, the findings support the hypothesis that body temperature alterations may be relevant to depression and could inform new treatment approaches. The study highlights the need for further research to clarify the biological pathways through which body temperature is altered in individuals with depression.